Wang Lu, Wang Xiancheng, Su Hongyan, Xu Jing
Department of Cardiology, The Third Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China.
ESC Heart Fail. 2024 Dec;11(6):3796-3804. doi: 10.1002/ehf2.14935. Epub 2024 Jul 15.
We aim to investigate the association between vitamin A intake and depression among patients with heart failure (HF).
In this cross-sectional study, data of HF patients were extracted from the National Health and Nutrition Examination Survey (NHANES) 2007-2020. The independent variable was vitamin A intake, and the dependent variable was depression. Weighted univariate and multivariate logistic regression models were performed to explore the association of vitamin A intake with depression in HF patients. A total of 999 HF patients were included, with a mean age of 66.19 (0.51) years, and 566 (52.49%) were male. And 197 patients have depression. Vitamin A intake ≥731.38 mcg was associated with lower incidence of depression [odds ratio (OR) = 0.37; 95% confidence interval (CI): 0.18-0.76] in HF patients. Similarly, the relationship between high vitamin A intake and lower odds of depression were also observed in subgroups of those aged >65 years (OR = 0.16; 95% CI: 0.04-0.55), males (OR = 0.35; 95% CI: 0.14-0.86), without hypertension (OR = 0.25; 95% CI: 0.11-0.58), without diabetes (OR = 0.30; 95% CI: 0.11-0.78), with hyperlipidaemia (OR = 0.23; 95% CI: 0.09-0.64), and with chronic kidney disease (CKD) (OR = 0.32; 95% CI: 0.13-0.80).
High vitamin A intake was associated with lower odds of depression in HF patients. Appropriate vitamin A supplementation may have potential benefit to the prevention of depression in HF patients. Additional prospective large-scale studies are required to confirm whether or not vitamin A could lead to decrease in depression symptoms.
我们旨在研究心力衰竭（HF）患者维生素A摄入量与抑郁症之间的关联。
在这项横断面研究中，从2007 - 2020年美国国家健康与营养检查调查（NHANES）中提取HF患者的数据。自变量为维生素A摄入量，因变量为抑郁症。采用加权单因素和多因素逻辑回归模型探讨HF患者维生素A摄入量与抑郁症之间的关联。共纳入999例HF患者，平均年龄为66.19（0.51）岁，其中男性566例（52.49%）。197例患者患有抑郁症。HF患者中，维生素A摄入量≥731.38微克与较低的抑郁症发病率相关[比值比（OR）= 0.37；95%置信区间（CI）：0.18 - 0.76]。同样，在年龄>65岁的亚组（OR = 0.16；95% CI：0.04 - 0.55）、男性亚组（OR = 0.35；95% CI：0.14 - 0.86）、无高血压亚组（OR = 0.25；95% CI：0.11 - 0.58）、无糖尿病亚组（OR = 0.30；95% CI：0.11 - 0.78）、高脂血症亚组（OR = 0.23；95% CI：0.09 - 0.64）以及慢性肾脏病（CKD）亚组（OR = 0.32；95% CI：0.13 - 0.80）中也观察到高维生素A摄入量与较低的抑郁症发病几率之间的关系。
HF患者高维生素A摄入量与较低的抑郁症发病几率相关。适当补充维生素A可能对预防HF患者抑郁症有潜在益处。需要更多前瞻性大规模研究来证实维生素A是否能减轻抑郁症症状。
