维生素D对心力衰竭患者心脏功能的影响：10项随机对照试验的系统评价和荟萃分析
Vitamin D on Cardiac Function in Heart Failure: A Systematic Review and Meta-Analysis of 10 RCTs.
作者信息
Chen Xuemeng, Zhao Wenli, Zhao Yan, Ma Jingchao, Bu Huaien, Zhao Ye
机构信息
Department of Public Health, International College, Krirk University, 10220 Bangkok, Thailand.
Liver Center, Saga University Hospital, Saga University, 849-8501 Saga, Japan.
出版信息
Rev Cardiovasc Med. 2023 Nov 23;24(11):325. doi: 10.31083/j.rcm2411325. eCollection 2023 Nov.
BACKGROUND
Systematic evaluation of the effects of vitamin D supplementation in heart failure (HF) patients.
METHODS
Searches were conducted on National Library of Medicine, Web of Science, Cochrane Library, Google Scholar, China National Knowledge Infrastructure, and WANFANG databases. We analyzed data by using Review Manager 5.4 software. All are from the earliest records to March 2023. Outcome indicators analyzed the left ventricular ejection fraction (LVEF), the left ventricular end-diastolic internal diameter (LVEDD), the B-type brain natriuretic peptide (BNP) level and the 25-hydroxy vitamin D (25(OH)D) level.
RESULTS
Ten studies with 1099 patients were included. LVEF (mean difference (MD) = 0.74, 95% CI: -0.29 to 1.76, = 0.41), LVEDD (MD = -0.59, 95% CI: -1.83 to 0.66, = 0.25), BNP (MD = -0.08, 95% CI: -0.24 to 0.08, = 0.34), 25(OH)D (MD = 0.41, 95% CI: -0.28 to 1.11, = 0.25) are not statistically significant. And there is no heterogeneity in the results of LVEF, LVEDD and BNP indicators.
CONCLUSIONS
Vitamin D supplementation may not be helpful in the clinical management of patients with HF.
背景
对心力衰竭（HF）患者补充维生素D的效果进行系统评价。
方法
检索美国国立医学图书馆、科学网、考克兰图书馆、谷歌学术、中国知网和万方数据库。我们使用Review Manager 5.4软件分析数据。所有数据均来自最早记录至2023年3月。结局指标分析左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）、B型脑钠肽（BNP）水平和25-羟维生素D（25(OH)D）水平。
结果
纳入10项研究，共1099例患者。LVEF（平均差值（MD）=0.74，95%置信区间：-0.29至1.76，P=0.41）、LVEDD（MD=-0.59，95%置信区间：-1.83至0.66，P=0.25）、BNP（MD=-0.08，95%置信区间：-0.24至0.08，P=0.34）、25(OH)D（MD=0.41，95%置信区间：-0.28至1.11，P=0.25）差异均无统计学意义。且LVEF、LVEDD和BNP指标结果无异质性。
结论
补充维生素D可能无助于HF患者的临床管理。
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