DeSomma Anthony, Lee Jeung Woon
Anatomy, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
School of Dental Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
Cureus. 2025 Jul 14;17(7):e87889. doi: 10.7759/cureus.87889. eCollection 2025 Jul.
Cardiovascular disease and aging are key contributors to myocardial remodeling, often leading to fibrosis, cellular hypertrophy, and impaired cardiac function. Understanding these structural changes is essential for explaining the pathophysiology of heart failure. This study examined histopathological changes in myocardial tissue from a post-mortem cadaver with heart failure. Two age-matched cadavers without cardiac disease were used as controls. Ventricular tissue samples were thin-sectioned and stained for collagen deposition and cellular morphology using Masson's Trichrome and Cresyl Violet dyes. Histopathological findings showed the presence of increased collagen deposition and fibrosis in the myocardial tissue with heart failure, consistent with a stiffened myocardium. Additionally, Cresyl Violet staining showed cardiomyocyte hypertrophy compared to control samples, suggesting cellular remodeling, which is well characterized following heart failure. These findings provide further histological evidence of myocardial remodeling in heart failure, characterized by fibrosis and cardiomyocyte hypertrophy. Further quantitative analysis is needed to deepen our understanding of these pathological changes and their implications for cardiac function.
心血管疾病和衰老都是心肌重塑的关键因素，常常导致纤维化、细胞肥大以及心脏功能受损。了解这些结构变化对于解释心力衰竭的病理生理学至关重要。本研究检查了一名心力衰竭尸检尸体心肌组织的组织病理学变化。选取两名年龄匹配的无心脏病尸体作为对照。将心室组织样本制成薄片，使用Masson三色染色法和甲酚紫染料对胶原沉积和细胞形态进行染色。组织病理学结果显示，心力衰竭心肌组织中胶原沉积和纤维化增加，这与心肌僵硬一致。此外，与对照样本相比，甲酚紫染色显示心肌细胞肥大，提示细胞重塑，这在心力衰竭后表现明显。这些发现为心力衰竭时以纤维化和心肌细胞肥大特征的心肌重塑提供了进一步的组织学证据。需要进一步的定量分析来加深我们对这些病理变化及其对心脏功能影响的理解。
