Raaphorst G P, Azzam E I
Radiat Res. 1985 Dec;104(3):449-54.
C3H 10T 1/2 cells were exposed to a wide range of anisotonic NaCl solutions and were irradiated during the last few minutes of the salt treatment. Radiosensitization in terms of cell killing and transformation was observed for hypotonic NaCl treatment. Hypertonic treatment with 0.5 mol/liter NaCl also caused radiosensitization for cell killing and transformation, while extreme hypertonic treatment (1.5 mol/liter) resulted in radioprotection for both end points. Radiosensitization for both end points declined as the hypotonic treatment (0.05 mol/liter) was prolonged. To a lesser extent, a decline in radioprotection by 1.5 mol/liter treatment occurred as exposure time increased.
将C3H 10T 1/2细胞暴露于一系列不同渗透压的氯化钠溶液中，并在盐处理的最后几分钟进行辐照。观察到低渗氯化钠处理在细胞杀伤和转化方面具有放射增敏作用。用0.5摩尔/升氯化钠进行高渗处理也会导致细胞杀伤和转化的放射增敏，而极端高渗处理（1.5摩尔/升）则对两个终点均产生放射保护作用。随着低渗处理（0.05摩尔/升）时间的延长，两个终点的放射增敏作用均下降。在较小程度上，随着暴露时间的增加，1.5摩尔/升处理的放射保护作用也会下降。
