Sun Changxu, Yue Jiping, Li Pengju, Li Wen, Ma Jingcheng, Yang Chuanwang, Kim Saehyun, Tian Bozhi
Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA.
Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Matter. 2025 Mar 5;8(3). doi: 10.1016/j.matt.2025.102002. Epub 2025 Feb 17.
Natural plants provide a wealth of valuable materials for healthcare, with much of their potential often overlooked in what is commonly considered waste. This study focuses on the (), whose fruit, (PDH), has long been used in traditional Chinese medicine. By investigating PDH husk's swelling behavior, we efficiently extracted its polysaccharides without harsh chemicals. Using micro-compression, we developed a viscoelastic hydrogel, and through electrostatic crosslinking with chitosan, we further enhanced its mechanical properties. The hydrogel exhibited biocompatibility and accelerated wound healing by promoting keratinocyte migration. Additionally, it outperformed commercial patches as a skin-attached interfacial material for electrocardiography (ECG), demonstrating superior signal-to-noise ratios. Integrated into a 16-channel mesh-electronic device, the hydrogel provided stable performance for epicardial ECG recording on a beating heart. This research highlights the potential of rigid polysaccharide waste, presenting a sustainable approach to converting plant waste into valuable healthcare materials.
天然植物为医疗保健提供了丰富的宝贵材料，其许多潜力在通常被视为废物的东西中常常被忽视。本研究聚焦于（），其果实（PDH）长期以来一直用于传统中药。通过研究PDH果壳的溶胀行为，我们在不使用苛刻化学物质的情况下高效提取了其多糖。利用微压缩，我们开发了一种粘弹性水凝胶，并通过与壳聚糖进行静电交联，进一步增强了其机械性能。该水凝胶表现出生物相容性，并通过促进角质形成细胞迁移加速伤口愈合。此外，作为用于心电图（ECG）的皮肤附着界面材料，它优于商业贴片，显示出卓越的信噪比。集成到一个16通道网状电子设备中，该水凝胶在跳动的心脏上进行心外膜ECG记录时提供了稳定的性能。这项研究突出了刚性多糖废物的潜力，提出了一种将植物废物转化为有价值的医疗保健材料的可持续方法。
