Geng Jiawei, Liu Mingzhu, Jin Siyan, Xu Wenjing, Yang Peizeng, Liu Xiaoli
Ophthalmologic Center of the Second Hospital, Jilin University, Changchun, P.R. China.
Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
Ocul Immunol Inflamm. 2025 Aug 15:1-7. doi: 10.1080/09273948.2025.2545518.
To investigate ultrawidefield optical coherence tomography angiography (UWF-OCTA) changes in the mid-periphery of new-onset active Vogt-Koyanagi-Harada (VKH) patients.
New-onset and untreated active VKH patients were continuously observed using UWF-OCTA at 2 weeks, 1, and 3 months after treatment.
Twenty-four new-onset and untreated active VKH patients were included. Seven inactive VKH patients with sunset glow fundus (SGF), and 10 age-sex-matched normal people served as controls. In active VKH patients, there was a significant change in choroidal flow but no change in retinal flow in the mid-periphery before treatment. Vascular density of large- and medium-sized choroidal vessels (LMCV-VD) in mid-periphery, along with retinal and choroidal capillaries in macula, was decreased. Retinal and choroidal thickness in both macula and mid-periphery were increased (all < 0.05). After 2 weeks of treatment, the parameters of the retina and choroid in both the mid-periphery and the macula were significantly improved. Retinal thickness and LMCV-VD recovered sequentially: first in the macular and temporal regions, followed by the nasal area. Deep capillary plexus-VD in the macula at 3 months of treatment was correlated with visual acuity ( = 0.699, = 0.002). Binary logistic regression ( = 0.044, OR = 2.695, 95% CI95% CI = 1.027 ~ 7.056) analyses revealed that LMCV-VD at 2 weeks of treatment was associated with the prediction of SGF.
In active VKH patients, the parameters of the retina and choroid were altered in both mid-periphery and macula. After treatment, the temporal side was prioritized for recovery. LMCV-VD at two weeks of treatment had the potential to predict the SGF.
研究初发性活动性Vogt-小柳-原田病（VKH）患者中周部的超广角光学相干断层扫描血管造影（UWF-OCTA）变化。
对初发性且未经治疗的活动性VKH患者在治疗后2周、1个月和3个月时使用UWF-OCTA进行连续观察。
纳入24例初发性且未经治疗的活动性VKH患者。7例有晚霞样眼底（SGF）的非活动性VKH患者和10例年龄及性别匹配的正常人为对照组。在活动性VKH患者中，治疗前中周部脉络膜血流有显著变化，但视网膜血流无变化。中周部大、中型脉络膜血管（LMCV-VD）以及黄斑区视网膜和脉络膜毛细血管的血管密度降低。黄斑区和中周部的视网膜和脉络膜厚度均增加（均P＜0.05）。治疗2周后，中周部和黄斑区的视网膜和脉络膜参数均显著改善。视网膜厚度和LMCV-VD依次恢复：首先是黄斑区和颞侧区域，随后是鼻侧区域。治疗3个月时黄斑区深层毛细血管丛-VD与视力相关（r = 0.699，P = 0.002）。二元逻辑回归分析（P = 0.044，OR = 2.695，95%CI = 1.027～7.056）显示，治疗2周时的LMCV-VD与SGF的预测相关。
在活动性VKH患者中，中周部和黄斑区的视网膜和脉络膜参数均发生改变。治疗后，颞侧优先恢复。治疗2周时的LMCV-VD有可能预测SGF。
