Hirayama T, Roberts D, William-Olsson G
Scand J Thorac Cardiovasc Surg. 1985;19(3):253-6. doi: 10.3109/14017438509102727.
The haemolytic properties of mechanical and biologic valve prostheses are well established, and it is known that they can shorten red cell survival time (1, 2). Their effects on red cell deformability are not known, however. A comparative study was therefore made of two valve types--Björk-Shiley (BS) and Carpentier-Edwards (CE). Thirty-nine patients with normally functioning valve prostheses (23 BS, 16 CE) were studied at least one year after surgery, by assessing red cell deformability measured as red cell filtration rate (RFR), red cell survival half-time with the Cr-51 isotope method (Cr-51 T1/2) and plasma-haemoglobin (P-Hb). The BS valve was shown to be more traumatic to the cells than the CE valve and effected greater reduction of the deformability of these cells. Significant intercorrelations were found between RFR, CR-51 T1/2 and P-Hb.
机械瓣膜和生物瓣膜假体的溶血特性已得到充分证实，并且已知它们会缩短红细胞存活时间（1,2）。然而，它们对红细胞变形性的影响尚不清楚。因此，对两种瓣膜类型—— Björk-Shiley（BS）和Carpentier-Edwards（CE）进行了一项比较研究。对39例瓣膜假体功能正常的患者（23例BS型，16例CE型）在术后至少一年进行研究，通过评估以红细胞滤过率（RFR）衡量的红细胞变形性、采用Cr-51同位素法测定的红细胞存活半衰期（Cr-51 T1/2）以及血浆血红蛋白（P-Hb）。结果显示，BS瓣膜对细胞的损伤比CE瓣膜更大，并且使这些细胞的变形性降低得更多。在RFR、CR-51 T1/2和P-Hb之间发现了显著的相互关系。
