Roberts D, Bake B, William-Olsson G
Scand J Thorac Cardiovasc Surg. 1984;18(2):115-8. doi: 10.3109/14017438409102389.
Red cell survival was studied with use of Chromium-51 isotope and standard haematologic tests of haemolysis. The study comprised 30 patients with normally functioning single artificial heart valves of various types. They were investigated on 2 or 3 occasions. Red cells labelled with Cr-51 were treated for 30 min with potassium cyanate (0.5 mg/100 ml) in 5% invertose or with only 5% invertose. The mean red cell survival without cyanate treatment was 25 (+/- 4.2) days. Following cyanate treatment this figure improved to 31 (+/-4.8) days. Low-grade chronic intravascular haemolysis was associated with all the valve types. Abnormal results were found in 67% and 62% of the tests in patients with ball-type valve (deBakey and Starr-Edwards, respectively). The figures for tilting disc values (Lillehei-Kaster and Björk-Shiley) were 51 and 45.5%, while Carpentier-Edwards bioprosthetic valves gave 15.5% abnormal test results. The findings thus suggested that ball valves are more haemolytic than tilting disc valves, which in turn are more haemolytic than tissue valves.
使用铬 - 51同位素和标准溶血血液学检测方法对红细胞存活情况进行了研究。该研究纳入了30例使用各种类型正常运行的单个人造心脏瓣膜的患者。他们接受了2次或3次检查。用5%转化糖中的氰酸钾（0.5毫克/100毫升）或仅用5%转化糖对标记有铬 - 51的红细胞处理30分钟。未进行氰酸盐处理时，红细胞平均存活时间为25（±4.2）天。氰酸盐处理后，这一数字提高到31（±4.8）天。所有瓣膜类型均伴有轻度慢性血管内溶血。球型瓣膜患者（分别为德巴凯和斯塔尔 - 爱德华兹型）的检测中，异常结果分别占67%和62%。倾斜碟瓣（ Lillehei - Kaster和 Björk - Shiley型）的这一数字为51%和45.5%，而卡朋蒂埃 - 爱德华兹生物瓣膜的检测异常结果为15.5%。因此，研究结果表明球瓣比倾斜碟瓣的溶血作用更强，而倾斜碟瓣又比组织瓣膜的溶血作用更强。
