[2-¹⁴C-非那西泮的体外代谢]
[2-14C-phenazepam metabolism in vitro].
作者信息
Golovenko N Ia, Zin'kovskiĭ V G
出版信息
Farmakol Toksikol. 1979 Nov-Dec;42(6):597-600.
PMID:40817
Abstract
Phenazepam undergoes aromatic and C3-hydroxylation in the microsomes of albino rats. Saturation of phenazepam oxidising enzymes proceeds at different substrate concentrations for both processes. Interaction of cytochrome P-450 with phenazepam is accompanied by spectral changes in the type II hemoprotein.
摘要
非那西泮在白化大鼠微粒体中发生芳香族和C3-羟基化反应。非那西泮氧化酶的饱和在这两个过程的不同底物浓度下进行。细胞色素P-450与非那西泮的相互作用伴随着II型血红蛋白的光谱变化。
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