Golovenko N Ia, Meteshkin Iu V, Iakubovskaia L N
Vopr Med Khim. 1980 Sep-Oct;26(5):637-40.
Aromatic hydroxylation and oxidation of heterocyclic molecule of phenazepame were studied. The reaction of aromatic hydroxylation prevailed in microsomes of intact animals, whereas preinduction of rats using phenobarbital and 3-methylcholanthrene altered the phenazepame metabolism increasing the rate of oxidation in the heterocyclic ring. Kinetic parameters are described for oxidation of phenazepame molecule by both intact and induced rat microsomes.
