Yadav Priyanka, Warkar Sudhir G, Kumar Anil
Department of Applied Chemistry, Delhi Technological University, Delhi 110042, India.
Department of Applied Chemistry, Delhi Technological University, Delhi 110042, India.
Int J Biol Macromol. 2025 Sep;322(Pt 2):146662. doi: 10.1016/j.ijbiomac.2025.146662. Epub 2025 Aug 14.
This research aims to develop a novel smart pH-responsive carboxymethyl tamarind kernel gum/sodium alginate/polyacrylamide (CMTKG/SA/PAM) hydrogel, and the loading of azithromycin drug (AZM) was done to utilize the drug-loaded hydrogels in drug delivery. The effect of varying amounts of biopolymer (CMTKG), initiator, and crosslinker on the swelling behavior of hydrogels was assessed. The fabricated hydrogel was characterized using FTIR, PXRD, TGA, and SEM. The sol-gel analysis was also performed to identify the crosslinked portion in the hydrogel. Further, to check the pH responsiveness of the hydrogel, swelling and drug release studies were performed at pH 7.4 and 1.2, which revealed the pH-dependent behavior of the synthesized hydrogel, and the results revealed better swelling and drug release at pH 7.4 as compared to pH 1.2. The kinetic study reveals that experimental data fitted best with the Korsmeyer-Peppas and Higuchi models. In addition, the synthesized hydrogel demonstrated antibacterial properties. Hence, CMTKG/SA/PAM hydrogel can serve as a promising material for the pH-dependent release of model drugs.
本研究旨在开发一种新型的智能pH响应性羧甲基罗望子核胶/海藻酸钠/聚丙烯酰胺（CMTKG/SA/PAM）水凝胶，并对阿奇霉素药物（AZM）进行负载，以将载药凝胶用于药物递送。评估了不同量的生物聚合物（CMTKG）、引发剂和交联剂对水凝胶溶胀行为的影响。使用傅里叶变换红外光谱（FTIR）、粉末X射线衍射（PXRD）、热重分析（TGA）和扫描电子显微镜（SEM）对制备的水凝胶进行了表征。还进行了溶胶-凝胶分析，以确定水凝胶中的交联部分。此外，为了检查水凝胶的pH响应性，在pH 7.4和1.2下进行了溶胀和药物释放研究，结果表明合成水凝胶具有pH依赖性行为，且在pH 7.4时的溶胀和药物释放效果优于pH 1.2时。动力学研究表明，实验数据与Korsmeyer-Peppas模型和Higuchi模型拟合得最好。此外，合成水凝胶具有抗菌性能。因此，CMTKG/SA/PAM水凝胶可作为一种有前景的材料用于模型药物的pH依赖性释放。
