光谱异常：对NLRP3来说是一小步，但对人类成熟红细胞来说却是一大步。 - Suppr

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Spectosis: One small step for NLRP3 but a giant leap for human mature red blood cells.

作者信息

Chen Yaozhen, Zhang Jing, Hu Xingbin

机构信息

Department of Transfusion Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

出版信息

Clin Transl Med. 2025 Aug;15(8):e70457. doi: 10.1002/ctm2.70457.

DOI:10.1002/ctm2.70457

PMID:40820441

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12358677/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3b2/12358677/7c8fb0b5b72e/CTM2-15-e70457-g001.jpg

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Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition.

N Engl J Med. 2022 Jul 14;387(2):160-166. doi: 10.1056/NEJMra2201664.

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia.

Sci Transl Med. 2021 Oct 20;13(616):eabj1008. doi: 10.1126/scitranslmed.abj1008.

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Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20.

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相似文献

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Cell. 2025 May 29;188(11):3013-3029.e19. doi: 10.1016/j.cell.2025.03.039. Epub 2025 Apr 18.

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本文引用的文献

Red blood cells undergo lytic programmed cell death involving NLRP3.

Cell. 2025 May 29;188(11):3013-3029.e19. doi: 10.1016/j.cell.2025.03.039. Epub 2025 Apr 18.

A guide to cell death pathways.

Nat Rev Mol Cell Biol. 2024 May;25(5):379-395. doi: 10.1038/s41580-023-00689-6. Epub 2023 Dec 18.

Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition.

N Engl J Med. 2022 Jul 14;387(2):160-166. doi: 10.1056/NEJMra2201664.

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia.

Sci Transl Med. 2021 Oct 20;13(616):eabj1008. doi: 10.1126/scitranslmed.abj1008.

NINJ1 mediates plasma membrane rupture during lytic cell death.

Nature. 2021 Mar;591(7848):131-136. doi: 10.1038/s41586-021-03218-7. Epub 2021 Jan 20.

Hemolytic Transfusion Reactions.

N Engl J Med. 2019 Jul 11;381(2):150-162. doi: 10.1056/NEJMra1802338.

Novel mechanisms and functions of complement.

Nat Immunol. 2017 Nov 16;18(12):1288-1298. doi: 10.1038/ni.3858.

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Semin Cell Dev Biol. 2015 Mar;39:35-42. doi: 10.1016/j.semcdb.2015.01.009. Epub 2015 Jan 28.

Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes.

mBio. 2014 Aug 26;5(5):e01251-14. doi: 10.1128/mBio.01251-14.

A role for mitochondria in NLRP3 inflammasome activation.

Nature. 2011 Jan 13;469(7329):221-5. doi: 10.1038/nature09663. Epub 2010 Dec 1.