Shi Bin, Yu Wen, Qi Bei, Liu Huifang, Jiang Rui
Department of Otorhinolaryngology-Head and Neck Surgery, Northern Jiangsu People's Hospital Yangzhou 225001, Jiangsu, China.
Am J Transl Res. 2025 Jul 15;17(7):5475-5484. doi: 10.62347/PWLD5244. eCollection 2025.
To evaluate the efficacy of endoscopic minimally invasive surgery (EMIS) in improving olfactory function and quality of life among patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
A cohort of 117 patients diagnosed with CRSwNP between January 2020 and June 2024 were included in this retrospective study. Patients were assigned to either a control group (n=50, treated with conventional endoscopic sinus surgery [ESS]) or a research group (n=67, treated with EMIS). Comprehensive assessments were conducted, including treatment efficacy, safety profile, olfactory function, nasal ventilation (airway resistance), nasal status, stress biomarkers, and quality of life.
Compared to the control group, the research group showed significantly better outcomes in terms of: (1) overall therapeutic efficacy, (2) postoperative safety profile (lower postoperative complication rates), (3) olfactory function recovery, (4) nasal ventilation and functional status, (5) quality of life improvement, and (6) reduced surgical stress response (all P<0.05).
EMIS significantly improves olfactory function and quality of life in patients with CRSwNP, offering clinical advantages over conventional ESS and supporting its broader clinical application.
评估内镜微创手术（EMIS）对改善慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）患者嗅觉功能和生活质量的疗效。
本回顾性研究纳入了2020年1月至2024年6月期间诊断为CRSwNP的117例患者。患者被分为对照组（n = 50，接受传统内镜鼻窦手术[ESS]治疗）或研究组（n = 67，接受EMIS治疗）。进行了全面评估，包括治疗效果、安全性、嗅觉功能、鼻腔通气（气道阻力）、鼻腔状况、应激生物标志物和生活质量。
与对照组相比，研究组在以下方面显示出显著更好的结果：（1）总体治疗效果，（2）术后安全性（术后并发症发生率较低），（3）嗅觉功能恢复，（4）鼻腔通气和功能状态，（5）生活质量改善，以及（6）手术应激反应减轻（所有P < 0.05）。
EMIS显著改善了CRSwNP患者的嗅觉功能和生活质量，与传统ESS相比具有临床优势，支持其更广泛的临床应用。
