系膜IgA肾病中的抗凝血酶III

Antithrombin III in mesangial IgA nephritis.

作者信息

Woo K T, Lee E J, Lau Y K, Lim C H

出版信息

Thromb Res. 1985 Nov 15;40(4):483-7. doi: 10.1016/0049-3848(85)90285-3.

Abstract

Plasma Antithrombin III (A T III) was measured in 97 patients with IgA nephritis, 30 patients with non IgA idiopathic mesangial proliferative glomerulonephritis and 40 healthy subjects. The mean plasma A T III levels in the patients with IgA nephritis (105 +/- 10%) was significantly higher than those of normal controls (96 +/- 5%) (p less than 0.0005). The mean plasma A T III levels in the patients with non IgA nephritis (101 +/- 10%) was not different from those of the normal controls or the patients with IgA nephritis. A T III levels were significantly correlated with proteinuria (p less than 0.0001), segmental sclerosis (p less than 0.001), crescents (p less than 0.01), medial hypertrophy (p less than 0.001) and intensity of IgA staining on IMF (p less than 0.02). Patients with IgA nephritis with raised A T III levels had significantly more proteinuria (p less than 0.003), more segmental sclerosis (p less than 0.007) as well as a greater intensity of IgA staining on IMF (p less than 0.02) when compared to patients with normal A T III levels. The data suggest that raised plasma A T III levels may serve as a prognostic marker in IgA nephritis.

摘要

对97例IgA肾病患者、30例非IgA特发性系膜增生性肾小球肾炎患者及40名健康受试者测定了血浆抗凝血酶III（AT III）。IgA肾病患者的血浆AT III平均水平（105±10%）显著高于正常对照组（96±5%）（p<0.0005）。非IgA肾病患者的血浆AT III平均水平（101±10%）与正常对照组或IgA肾病患者无异。AT III水平与蛋白尿（p<0.0001）、节段性硬化（p<0.001）、新月体（p<0.01）、血管壁中层肥厚（p<0.001）及免疫荧光显微镜下IgA染色强度（p<0.02）显著相关。与AT III水平正常的IgA肾病患者相比，AT III水平升高的IgA肾病患者蛋白尿更多（p<0.003）、节段性硬化更多（p<0.007），且免疫荧光显微镜下IgA染色强度更高（p<0.02）。数据表明，血浆AT III水平升高可能是IgA肾病的一个预后标志物。