Lorusso L, Miniello V L, Francioso G, Aceto G, DiBitonto G, Penza R
Boll Soc Ital Biol Sper. 1982 Sep 15;58(17):1093.
In the Nephrotic Syndrome an hypercoagulable state can cause an increased incidence of thromboembolic phenomena and the course of the syndrome. The deficiency of Antithrombin III has been suggested to explain the hypercoagulability. We measured plasma antithrombin concentration (as percentage) in 24 children suffering from N.S. and the values were correlated with serum albumin, proteinuria and Partial Thromboplastin Time (PTT). The results of this study show that plasma Antithrombin III (AT-III) is significantly correlated with serum albumin, with proteinuria and PTT. Moreover plasma AT-III concentration was found to be low particularly when patients relapsed and in 2 children who developed thombophlebitis of the safena vein.
在肾病综合征中，高凝状态可导致血栓栓塞现象的发生率增加，并影响综合征的病程。抗凝血酶III缺乏被认为可解释高凝状态。我们测定了24例肾病综合征患儿的血浆抗凝血酶浓度（以百分比表示），并将这些值与血清白蛋白、蛋白尿和部分凝血活酶时间（PTT）进行了关联。本研究结果表明，血浆抗凝血酶III（AT-III）与血清白蛋白、蛋白尿和PTT显著相关。此外，发现血浆AT-III浓度较低，尤其是在患者复发时，以及在2例发生股静脉血栓性静脉炎的患儿中。
