酷似Lhermitte-Duclos病影像学表现的小脑节细胞胶质瘤：一例报告并文献复习
Cerebellar ganglioglioma mimicking the radiographic appearance of Lhermitte-Duclos disease: A case report and review of literature.
作者信息
Gharib Amin, Bali Basem, Ghareeb Nour, Darwaze Mohammad, Yaish Mohsen, Othman Othman, Haj Razan, Jallad Firas
机构信息
Faculty of Medicine, An-Najah National University, Nablus, Palestine.
Neurosurgery department, Rafidia Surgical Hospital, Nablus, Palestine.
出版信息
Radiol Case Rep. 2025 Aug 8;20(11):5437-5443. doi: 10.1016/j.radcr.2025.07.019. eCollection 2025 Nov.
BACKGROUND
Lhermitte-Duclos disease (LDD) is a rare condition that typically presents with signs and symptoms of cerebellar dysfunction and elevated intracranial pressure. Magnetic resonance imaging (MRI) plays a pivotal role in the diagnosis of LDD as its characteristic "tiger-striped" appearance is believed to be diagnostic enough to eliminate the need for histopathological examination. We present a case of cerebellar ganglioglioma mimicking the distinct MRI appearance of LDD.
CASE REPORT
A 46-year-old female patient presented with increasing dizziness, blurred vision and headaches. An MRI scan demonstrated the presence of heterogeneous, nonenhancing mass with the characteristic "tiger-striped" appearance of LDD. However, after tumor resection, histopathological examination demonstrated that the tumor histological architecture resembles that of gangliogliomas rather than LDD, leading to an altered diagnosis and therapeutic approach.
CONCLUSION
LDD's "tiger-striped" might not be as unique as previously thought, and histopathological examination is essential for proper diagnosis, treatment and follow-up.
背景
Lhermitte-Duclos病（LDD）是一种罕见疾病，通常表现为小脑功能障碍和颅内压升高的体征及症状。磁共振成像（MRI）在LDD的诊断中起关键作用，因为其特征性的“虎纹”外观被认为足以确诊，无需进行组织病理学检查。我们报告一例模仿LDD独特MRI表现的小脑节细胞胶质瘤病例。
病例报告
一名46岁女性患者出现头晕、视力模糊和头痛加重症状。MRI扫描显示存在具有LDD特征性“虎纹”外观的不均匀、无强化肿块。然而，肿瘤切除后，组织病理学检查显示肿瘤组织学结构类似于节细胞胶质瘤而非LDD，从而改变了诊断和治疗方法。
结论
LDD的“虎纹”可能不像之前认为的那样独特，组织病理学检查对于正确的诊断、治疗和随访至关重要。
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