Karanikolic Vesna, Bakic Mirjana, Gluscevic Sanja, Mercantepe Filiz, Klisic Aleksandra
University of Nis-School of Medicine, Clinic for Skin Diseases of the Clinical Center Nis, Nis.
Clinical Center of Montenegro, Clinic for Dermatovenerology, Podgorica, Montenegro.
J Med Biochem. 2025 Jun 13;44(3):614-621. doi: 10.5937/jomb0-52038.
Patients with psoriasis are at an increased risk of cardiovascular disease (CVD). Psoriasis and atherosclerosis share the common soil of inflammation and oxidative stress in their pathogenesis. The current study aimed to examine cardiovascular risk concerning some non-traditional (i.e., biomarkers of oxidative stress and inflammation) and traditional metabolic parameters in patients with psoriasis.
A total of 68 (57% men) patients with psoriasis were included. Traditional metabolic parameters, markers of oxidative stress[i.e., oxidation protein products (AOPP), malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD)] and inflammation (C-reactive protein) were measured. The atherosclerotic cardiovascular disease (ASCVD) risk score was used to measure CVD risk. Patients were divided into ASCVD score tertiles.
Patients with a higher ASCVD score had significantly lower high-density lipoprotein cholesterol (HDL-C), higher triglycerides (TG), and higher TG/HDL-C ratio (p for trend p<0.001). Among redox status parameters, only AOPP showed a significant increase in parallel with the ASCVD score increase (p=0.011). In univariate binary logistic regression analysis, AOPP [OR, 95% CI=1.027 (1.004-1.051), p=0.021] and TG [OR, 95% CI =7.220 (2.041-25.548), p=0.002] correlated with the ASCVD risk score. In multivariate analysis (backward method), only TG was an independent predictor of ASCVD score [OR, 95%CI =7.220 (2.041-25.548), p=0.002].
The results show the association between ASCVD score and oxidative stress (AOPP) and dyslipidemia (TG), respectively, in patients with psoriasis, but only TG retained its independent association with ASCVD risk score. Measuring serum TG levels is very important in patients with increased ASCVD risk concerning psoriasis.
银屑病患者患心血管疾病（CVD）的风险增加。银屑病和动脉粥样硬化在发病机制上有炎症和氧化应激这一共同基础。本研究旨在探讨银屑病患者一些非传统（即氧化应激和炎症生物标志物）和传统代谢参数的心血管风险。
共纳入68例（57%为男性）银屑病患者。测量传统代谢参数、氧化应激标志物[即氧化蛋白产物（AOPP）、丙二醛（MDA）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）]以及炎症标志物（C反应蛋白）。采用动脉粥样硬化性心血管疾病（ASCVD）风险评分来衡量心血管疾病风险。患者被分为ASCVD评分三分位数组。
ASCVD评分较高的患者高密度脂蛋白胆固醇（HDL-C）显著降低，甘油三酯（TG）升高，TG/HDL-C比值升高（趋势p<0.001）。在氧化还原状态参数中，只有AOPP随ASCVD评分增加而显著升高（p=0.011）。在单变量二元逻辑回归分析中，AOPP[比值比（OR），95%置信区间（CI）=1.027（1.004 - 1.051），p=0.021]和TG[OR，95%CI =7.220（2.041 - 25.548），p=0.002]与ASCVD风险评分相关。在多变量分析（向后法）中，只有TG是ASCVD评分的独立预测因子[OR，95%CI =7.220（2.041 - 25.548），p=0.002]。
结果表明，银屑病患者中ASCVD评分分别与氧化应激（AOPP）和血脂异常（TG）相关，但只有TG与ASCVD风险评分保持独立关联。对于银屑病患者中ASCVD风险增加的患者，检测血清TG水平非常重要。
