Wang Mingyu, Zhou Xian, Hübertz Birch Hansen Lea, Sheng Yongshuai, Yu Bing, He Jun, Yu Jie, Zheng Ping
Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, and Key Laboratory of Animal Disease-Resistant Nu-trition, Chengdu, Sichuan, China.
Animal and Plant Health & Nutrition, Chr. Hansen A/S, Hoersholm, Denmark.
Front Immunol. 2025 Aug 1;16:1629044. doi: 10.3389/fimmu.2025.1629044. eCollection 2025.
PURPOSE: SOLVENS (SLV) is a zootechnical feed additive based on viable spores of and . This study aimed to evaluate the effects of SLV on the intestinal health of weaned piglets. METHODS: A total of 360 healthy 24-day-old weaned Duroc × Landrace × Yorkshire piglets were allocated to three treatment groups based on body weight and sex: T1 (Control, CON), T2 (SLV 200, 6.5×10 CFU per kg feed), and T3 (SLV 400, 1.3×10 CFU per kg feed). Each treatment consisted of 30 replicates with four pigs per replicate, and the experiment lasted 42 days. Piglets were fed mash pre-starter feed (days 1-14) and mash starter feed (days 15-42). Growth performance, fecal microorganisms, serum immunity, and intestinal barrier function were assessed. Experimental data were analyzed using SPSS 27.0 for one-way ANOVA, and multiple comparisons were made using the DUNCAN method. RESULTS: Compared with the control, SLV 200 and SLV 400 significantly reduced diarrhea rate ( < 0.05). SLV 200 increased fecal and decreased on day 14 ( < 0.05), while SLV 400 elevated on days 14 and 42 and reduced on day 14 ( < 0.05). SLV 200 increased fecal sIgA and serum IgG on day 42 ( < 0.05), whereas SLV 400 elevated serum IgG and IgM on day 14 ( < 0.05) and serum IgA on day 42 ( < 0.05). Additionally, SLV 200 downregulated ileal () and () gene expression ( < 0.05), and SLV 400 reduced expression ( < 0.05). CONCLUSION: Dietary supplementation with SLV improved intestinal health by modulating gut microbiota and enhancing immunity in weaned piglets.
目的：SOLVENS（SLV）是一种基于[具体两种微生物名称未给出]活孢子的畜牧饲料添加剂。本研究旨在评估SLV对断奶仔猪肠道健康的影响。 方法：将360头24日龄健康的杜洛克×长白×约克夏断奶仔猪按体重和性别分为三个处理组：T1（对照组，CON）、T2（SLV 200，每千克饲料含6.5×10[此处CFU的指数缺失]CFU）和T3（SLV 400，每千克饲料含1.3×10[此处CFU的指数缺失]CFU）。每个处理组有30个重复，每个重复4头猪，实验持续42天。仔猪在第1 - 14天饲喂预启始期粉料，在第15 - 42天饲喂启始期粉料。评估生长性能、粪便微生物、血清免疫和肠道屏障功能。实验数据使用SPSS 27.0进行单因素方差分析，并采用邓肯法进行多重比较。 结果：与对照组相比，SLV 200和SLV 400显著降低腹泻率（P < 0.05）。SLV 200在第14天增加粪便[某种物质名称未给出]并降低[某种物质名称未给出]（P < 0.05），而SLV 400在第14天和第42天提高[某种物质名称未给出]并在第14天降低[某种物质名称未给出]（P < 0.05）。SLV 并在第42天增加粪便分泌型免疫球蛋白A（sIgA）和血清免疫球蛋白G（IgG）（P < 0.05），而SLV 400在第14天提高血清IgG和免疫球蛋白M（IgM）（P < 0.05），在第42天提高血清IgA（P < 0.05）。此外，SLV 200下调回肠[基因名称未给出]（[基因名称未给出]）和[基因名称未给出]（[基因名称未给出]）基因表达（P < 0.05），SLV 400降低[基因名称未给出]表达（P < 0.05）。 结论：在断奶仔猪日粮中添加SLV可通过调节肠道微生物群和增强免疫力来改善肠道健康。
Zotero 插件
