Guo Jincheng, He Saiying, Zhou Jia, Liu Hao, Li Zixuan, Liu Zijing, Wang Senhu, Wang Haotian
Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Emergency Department, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Front Cardiovasc Med. 2025 Jul 31;12:1621424. doi: 10.3389/fcvm.2025.1621424. eCollection 2025.
Achieving optimal optical coherence tomography (OCT) imaging in patients with severe coronary stenosis is challenging because of the catheter-induced restriction of distal contrast flushing within the lesion.
To evaluate the effectiveness of manual contrast injection followed by OCT catheter advancement in improving image clarity in patients with severe coronary stenosis.
This single-centre observational study included 60 patients with acute coronary syndrome who demonstrated antegrade thrombolysis in myocardial infarction (TIMI) flow ≥2 on coronary angiography before the OCT catheter was passed through the severe coronary lesions. Catheter advancement resulted in TIMI 0-1 flow. A 7-step "P" technique was developed and implemented to optimise OCT imaging clarity, using manual contrast injection followed by catheter advancement distal to the region of interest (ROI). Image quality was evaluated using a semi-quantitative scoring system to assess the number of quadrants (0-4) in which the vessel walls were clearly visualised.
A total of 1,722 OCT frames were meticulously analysed, with a mean ROI length of 18.99 ± 8.82 mm. This technique consistently produced high-quality images with an average quality score of 3.88 ± 0.38. The proximal lesion segment generally showed a slightly higher image quality compared to the distal segment, with both regions achieving reasonably high clarity scores (3.90 ± 0.28 vs. 3.85 ± 0.45, < 0.001), though the clinical relevance of this difference is minimal. No complications occurred.
The 7-step "P" technique with manual injection is a safe and effective method for acquiring high-quality OCT images in patients with severe coronary artery stenosis, offering a practical alternative in clinical practice.
在严重冠状动脉狭窄患者中实现最佳光学相干断层扫描(OCT)成像具有挑战性,因为导管会导致病变内远端造影剂冲洗受限。
评估手动注射造影剂后推进OCT导管对改善严重冠状动脉狭窄患者图像清晰度的有效性。
这项单中心观察性研究纳入了60例急性冠状动脉综合征患者,这些患者在OCT导管穿过严重冠状动脉病变之前,冠状动脉造影显示心肌梗死溶栓(TIMI)血流≥2级。导管推进导致TIMI 0-1级血流。开发并实施了一种7步“P”技术,以优化OCT成像清晰度,即先手动注射造影剂,然后将导管推进到感兴趣区域(ROI)的远端。使用半定量评分系统评估图像质量,以评估血管壁清晰可见的象限数量(0-4个)。
共精心分析了1722个OCT图像帧,ROI平均长度为18.99±8.82毫米。该技术始终能产生高质量图像,平均质量评分为3.88±0.38。近端病变节段的图像质量通常略高于远端节段,两个区域的清晰度评分都相当高(3.90±0.28对3.85±0.45,<0.001),不过这种差异的临床相关性极小。未发生并发症。
采用手动注射的7步“P”技术是在严重冠状动脉狭窄患者中获取高质量OCT图像的一种安全有效的方法,为临床实践提供了一种实用的替代方案。