Gaggi Naomi L, Parincu Zamfira, Peterson Anna, O'Brien Courtney, Kam Korey, Tural Umit, Ayappa Indu, Varga Andrew W, Iosifescu Dan V, Osorio Ricardo S
Grossman School of Medicine, New York University, New York, NY, United States.
Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Behav Neurosci. 2025 Jul 31;19:1542462. doi: 10.3389/fnbeh.2025.1542462. eCollection 2025.
Disruptions in sleep are common across clinical populations, particularly those with neurological and psychiatric disorders, making restorative sleep and sustained wakefulness a public health priority. Sleep is essential for brain function, impacting cognition in addition to serving as a critical factor in memory consolidation and healthy aging. Neuromodulation via transcranial photobiomodulation (t-PBM) increases cerebral mitochondrial activity and blood flow. These effects may underlie improvements in sleep quality and wakefulness observed after t-PBM. In this systematic review, we summarize the current literature across clinical and healthy populations, which describes t-PBM's potential to improve sleep, wakefulness, and cognition. The scope of this review also includes t-PBM's effect on the brain's glymphatic system and blood flow, the potential of this strategy to augment alertness, wakefulness, and associated cognitive processes, and the suggestion for targeted t-PBM application for future research based on the underlying neurobiological mechanisms of t-PBM and wakefulness across diverse clinical populations.
睡眠中断在临床人群中很常见，尤其是那些患有神经和精神疾病的人群，这使得恢复性睡眠和持续清醒成为公共卫生的优先事项。睡眠对大脑功能至关重要，除了作为记忆巩固和健康衰老的关键因素外，还会影响认知。通过经颅光生物调节（t-PBM）进行神经调节可增加脑线粒体活性和血流量。这些效应可能是t-PBM后观察到的睡眠质量和清醒状态改善的基础。在本系统评价中，我们总结了临床和健康人群的现有文献，这些文献描述了t-PBM改善睡眠、清醒和认知的潜力。本评价的范围还包括t-PBM对大脑类淋巴系统和血流量的影响、该策略增强警觉性、清醒和相关认知过程的潜力，以及基于t-PBM的潜在神经生物学机制和不同临床人群的清醒状态，对未来研究中靶向t-PBM应用的建议。
