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一名患有严重登革热且有多种危险因素的患者发生侵袭性鼻及鼻窦毛霉菌病:病例报告及文献综述

Invasive nasal and paranasal mucormycosis in a patient with severe dengue fever and multiple risk factors: A case report and literature review.

作者信息

Tran Van Giang, Vu Dinh Phu, Dong Phu Khiem, Pham Van Phuc, Mac Duy Hung, Nguyen Quoc Phuong

机构信息

Infectious Department, Hanoi Medical University, No. 1 Ton That Tung, Dong Da, Hanoi, Viet Nam.

Department of Intensive Care, National Hospital of Tropical Diseases, Bau Village, Kim Chung, Dong Anh, Hanoi, Viet Nam.

出版信息

Med Mycol Case Rep. 2025 Aug 6;49:100724. doi: 10.1016/j.mmcr.2025.100724. eCollection 2025 Sep.

Abstract

Mucormycosis is a rare, life-threatening opportunistic fungal infection with high mortality rates that primarily affects immunocompromised patients. The co-occurrence of dengue fever and mucormycosis is extremely rare, with only a few cases reported worldwide. We report a case of a 50-year-old female diagnosed with mucormycos following dengue fever. To our knowledge, this is the first case report of invasive rhino-orbital mucormycosis following severe dengue fever in Vietnam. This case emphasizes the importance of close monitoring for opportunistic infections in patients with severe dengue fever and the necessity of combining antifungal therapy with surgical debridement to improve outcomes.

摘要

毛霉菌病是一种罕见的、危及生命的机会性真菌感染,死亡率很高,主要影响免疫功能低下的患者。登革热和毛霉菌病同时出现极为罕见,全球仅报告了少数病例。我们报告一例50岁女性在患登革热后被诊断为毛霉菌病的病例。据我们所知,这是越南首例关于严重登革热后发生侵袭性鼻眶毛霉菌病的病例报告。该病例强调了对重症登革热患者密切监测机会性感染的重要性,以及将抗真菌治疗与手术清创相结合以改善治疗效果的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11af/12355410/04ef4886233b/gr1.jpg

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