Fodor István, Markov Gabriel V, Yañez-Guerra Luis Alfonso, Elekes Károly, Pollák Edit, Molnár László, Pirger Zsolt
Ecophysiological and Environmental Toxicological Research Group, HUN-REN Balaton Limnological Research Institute, Tihany, Hungary.
Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, Roscoff, France.
Front Endocrinol (Lausanne). 2025 Jul 31;16:1627166. doi: 10.3389/fendo.2025.1627166. eCollection 2025.
Recently, critical evaluations have challenged the presence of vertebrate-type sex steroid signaling in mollusks, underlying the need of new research lines to shed light on molluscan endocrinology. The investigation of cholesterol metabolism and the potential biological role of sterols in mollusks has emerged as a growing research field in recent years. However, there is no clear consensus on several aspects of this topic and there is a great lack of relevant molecular data. In this perspective paper, we present an overview of our current knowledge on the role of cholesterol and sterols in mollusks and try to outline possible future research directions in molluscan endocrinology. Our study also provides a framework for studying cholesterol synthesis, uptake, transport, and metabolism in mollusks.
最近，批判性评估对软体动物中脊椎动物型性类固醇信号的存在提出了质疑，这凸显了开展新的研究方向以阐明软体动物内分泌学的必要性。近年来，对软体动物胆固醇代谢及固醇潜在生物学作用的研究已成为一个不断发展的研究领域。然而，在该主题的几个方面尚无明确共识，且极度缺乏相关分子数据。在这篇观点论文中，我们概述了目前关于胆固醇和固醇在软体动物中作用的知识，并试图勾勒出软体动物内分泌学未来可能的研究方向。我们的研究还为研究软体动物胆固醇的合成、摄取、运输和代谢提供了一个框架。
