Zhao Qiao-Ying, Zhao Bing, Wu Gang
Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Department of Ultrasound, Zhengzhou University People's Hospital, Zhengzhou, China.
Ann Med. 2025 Dec;57(1):2544879. doi: 10.1080/07853890.2025.2544879. Epub 2025 Aug 18.
To investigate the predictive value of shear wave elastography and molecular subtypes for the postoperative efficacy of neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC).
A total of 57 patients with BC undergoing NAC were retrospectively recruited. The general and follow-up data of these patients were collected. The patients were divided into two groups: the pathological complete remission (pCR) group and the non-pCR group.
There were significant differences in the proportion of the elastic modulus value ( = 0.005), Ki-67 expression level ( = 0.039) and molecular subtypes ( < 0.001) between the two groups. Patients with a high elastic modulus value, a high Ki-67 level, as well as triple-negative and human epidermal growth factor receptor 2-positive BC were associated with poor overall survival and disease-free survival time ( < 0.05). Logistic regression analysis identified the elastic modulus value (odds ratio [OR]: 5.841 [3.714-6.112], < 0.05), Ki-67 level (OR: 3.522 [1.865-3.897], < 0.05) and molecular subtypes (OR: 4.331 [2.552-6.714], < 0.05) as risk factors; logistic regression analysis also performed favourably for the prediction of pCR (area under the curve: 0.922 [0.871-0.934]) in patients with BC.
Elastic modulus value, Ki-67 level and molecular subtypes are risk factors for pCR in patients with BC.
探讨剪切波弹性成像及分子亚型对乳腺癌患者新辅助化疗（NAC）术后疗效的预测价值。
回顾性纳入57例行NAC的乳腺癌患者。收集这些患者的一般资料及随访数据。将患者分为两组：病理完全缓解（pCR）组和非pCR组。
两组间弹性模量值比例（P = 0.005）、Ki-67表达水平（P = 0.039）及分子亚型（P < 0.001）存在显著差异。弹性模量值高、Ki-67水平高以及三阴性和人表皮生长因子受体2阳性乳腺癌患者的总生存期和无病生存期较差（P < 0.05）。Logistic回归分析确定弹性模量值（比值比[OR]：5.841[3.714 - 6.112]，P < 0.05）、Ki-67水平（OR：3.522[1.865 - 3.897]，P < 0.05）和分子亚型（OR：4.331[2.552 - 6.714]，P < 0.05）为危险因素；Logistic回归分析对乳腺癌患者pCR的预测也表现良好（曲线下面积：0.922[0.871 - 0.934]）。
弹性模量值、Ki-67水平和分子亚型是乳腺癌患者pCR的危险因素。
