Frostelid Vetle Christoffer, Wajdan Ali, Villegas-Martinez Manuel, Hammersboen Lars-Egil R, Espinoza Andreas, Grymyr Ole-Johannes H N, Halvorsen Per Steinar, Elle Ole Jakob, Remme Espen W
The Intervention Centre, Oslo University Hospital, Oslo, Norway.
Department of Informatics, University of Oslo, Oslo, Norway.
Ann Biomed Eng. 2025 Aug 18. doi: 10.1007/s10439-025-03828-6.
Assessment of the contractile function of the heart typically requires resource demanding techniques, such as invasive left ventricular catheterisation or intermittent medical imaging, and is therefore not readily available for continuous clinical or remote monitoring. Measurement of heart wall motion by use of an epicardially attached three-axis accelerometer has emerged as a promising tool for monitoring cardiac function; however, previous methods have often underutilised the spatial and temporal information contained in the measured signals, potentially limiting its clinical reliability. This work reconstructs the position of an epicardial accelerometer in 3D space in order to enable extraction of indices of cardiac function in a Lagrangian frame of reference. The standard deviation of Lagrangian acceleration throughout a heartbeat, , is introduced as a novel surrogate indicator of contractility as changes in correlated strongly with changes in the maximum rate of change in left ventricular pressure in animal data (n=29) spanning a variety of haemodynamic conditions. The reported findings of this proof-of-principle study may represent a first step towards long-term monitoring of contractile function and expands on the current repertoire of use for epicardially attached accelerometers as versatile, continuous, and autonomous monitoring devices.
评估心脏的收缩功能通常需要耗费资源的技术，如有创性左心室导管插入术或间歇性医学成像，因此难以用于持续的临床监测或远程监测。利用心外膜附着的三轴加速度计测量心脏壁运动已成为监测心脏功能的一种有前景的工具；然而，以往的方法常常未充分利用测量信号中包含的空间和时间信息，这可能会限制其临床可靠性。这项工作重建了心外膜加速度计在三维空间中的位置，以便能够在拉格朗日参考系中提取心脏功能指标。整个心跳过程中拉格朗日加速度的标准差 被引入作为收缩性的一种新的替代指标，因为在跨越各种血流动力学条件的动物数据（n = 29）中， 的变化与左心室压力最大变化率的变化密切相关。这项原理验证研究的报告结果可能代表了朝着长期监测收缩功能迈出的第一步，并扩展了目前将心外膜附着加速度计用作通用、连续和自主监测设备的应用范围。
