Benvenuti Mirko, Burlando Martina, Cozzani Emanuele Claudio
Section of Dermatology, Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.
FEMS Microbiol Lett. 2025 Jan 10;372. doi: 10.1093/femsle/fnaf089.
Here we describe the case reports of three patients, 35, 64, and 72 year old, respectively, who were presented to the dermatology clinic for suspected onychomycosis with discolored and hardened nails. Both light microscopic analysis of the samples taken and culture analysis on SDA and DTM media were carried out. Direct microscopic analysis revealed the presence of yeast cells in the interstitial space of keratinocytes. Culture examinations resulted in the isolation of yeasts of the genus Rhodotorula. Subsequent metabolic and morphological analysis was conducted to ascertain the identification of the genus and species as Rhodotorula mucilaginosa. The involvement of this opportunistic pathogen in cases of onychomycosis is considered very rare and usually regarded as incidental; however, it should not be ruled out as a possible cause in favor of the more common dermatophytes or Candida spp. infections.
在此，我们描述了三名患者的病例报告，他们的年龄分别为35岁、64岁和72岁，因指甲变色和变硬被怀疑患有甲癣而前往皮肤科诊所就诊。对采集的样本进行了光学显微镜分析，并在SDA和DTM培养基上进行了培养分析。直接显微镜分析显示角质形成细胞间隙中存在酵母细胞。培养检查分离出了红酵母属的酵母。随后进行了代谢和形态学分析，以确定该属和种为粘红酵母。这种机会性病原体在甲癣病例中的参与被认为非常罕见，通常被视为偶然情况；然而，不应排除其作为可能病因的可能性，而更倾向于更常见的皮肤癣菌或念珠菌属感染。
