Spitkovskiĭ D D, Zborovskaia I B
Vopr Onkol. 1985;31(12):44-9.
The paper is concerned with the analysis of expression of myc, myb, fos, ras and sis oncogenes in 11 gastric tumors of different histological patterns, 5 histologically-unaltered areas adjacent to tumor and in stomach tumor metastases into lymph nodes. A high frequency of myc, ras and fos oncogene expression was registered in all the types of tissue examined without any apparent signs of tissue specificity. The study failed to detect sis oncogene transcripts. The myb oncogene, generally dormant in solid tumors, was expressed in 2 gastric tumor metastases.
本文对11例不同组织学类型的胃肿瘤、肿瘤旁5个组织学无改变区域以及胃肿瘤淋巴结转移灶中myc、myb、fos、ras和sis癌基因的表达进行了分析。在所检测的所有组织类型中,均发现myc、ras和fos癌基因的高频率表达,且无明显的组织特异性迹象。该研究未检测到sis癌基因转录本。通常在实体瘤中处于休眠状态的myb癌基因,在2例胃肿瘤转移灶中表达。