[Enhancement of the antitumor effect of cyclophosphane in an experiment].

A significant antitumor effect of acetylcellulose microsphere-encapsulated cyclophosphamide was observed in the course of the studies carried out in 105 male Wistar rats bearing Walker's carcinosarcoma and PC-1 carcinoma. The effect is due to a high tissue level of the drug maintained for a long time as the drug uniformly passes through the porous microsphere wall. Local (intratumoral) treatment with cyclophosphamide is more effective than standard methods. The inhibitory effect of microsphere-enclosed cyclophosphamide on neoplastic growth is potentiated by tumor ischemia.