Tret'iakov A V, Golovatova V A, Filov V A
Vopr Onkol. 1982;28(3):86-8.
Hydrazine sulfate significantly potentiated antitumor effect of thiophosphamide in experiments on rats with Walker's tumor. The treatment with hydrazine sulfate (60 mg/kg) plus thiophosphamide (1 mg/kg) resulted in suppression of tumor growth up to 90%, the dosage of thiophosphamide being therapeutically ineffective. Following hydrazine sulfate treatment, the activity (pH: 7.0-7.5-7.75) derived from tumors doubled, as compared with control. Similar results were obtained with enzymatic preparations. The activities of DNP-stimulated ATPase and solubilized enzymes in rat liver were not influenced by treatment.
在对患有沃克氏肿瘤的大鼠进行的实验中，硫酸肼显著增强了硫代磷酰胺的抗肿瘤作用。用硫酸肼（60毫克/千克）加硫代磷酰胺（1毫克/千克）进行治疗，可使肿瘤生长抑制高达90%，而硫代磷酰胺的该剂量在治疗上是无效的。与对照组相比，经硫酸肼治疗后，肿瘤来源的活性（pH值：7.0 - 7.5 - 7.75）增加了一倍。用酶制剂也获得了类似结果。大鼠肝脏中DNP刺激的ATP酶和可溶酶的活性不受治疗影响。
