Aleshko-Ozhevskiĭ Iu P, Makhova N N, Sheviakova L V, Mamonova L G, Skurikhin I M
Vopr Pitan. 1985 Sep-Oct(5):58-63.
The results of 352 atomic-absorption measurements of the concentrations of 8 basic biometals in breast milk samples from women of different age were investigated by variation-statistical and correlative analysis. It was found that in all the cases the distribution patterns of biometals were asymmetric. K, Na, Fe and Mn were marked by logarithmic distributions, whereas Ca, Mg, Zn and Cu by power distributions with the index 1/2. That was determined most likely by the physicochemical nature of the mechanisms by which milk homeostasis was controlled. It was shown that in assumption about the normal distribution pattern, commonly accepted in practice, might lead to noticeable errors in quantitative assessments and to erroneous qualitative conclusions. The most probable concentrations of the metals and the width of their distribution showed alterations in time, dissimilar for different metals, including extremal alterations, with the concentrations of the test metals changing 1-5-fold and elementary relations up to 10-fold. For K-Na, Fe-Mn, Zn-Cu and Fe-Cu pairs the interelementary relations of the presumably biochemical nature were discovered, with the stability of those relations being dependent on the time of lactation. The data on variations in the balance of biometals can be used in the design of improved substitutes of breast milk and formula feeding adapted to babies of different age.
通过变异统计和相关分析，对不同年龄女性母乳样本中8种基本生物金属浓度的352次原子吸收测量结果进行了研究。结果发现，在所有情况下，生物金属的分布模式都是不对称的。钾、钠、铁和锰呈对数分布，而钙、镁、锌和铜呈指数为1/2的幂分布。这很可能是由控制乳汁内稳态的机制的物理化学性质决定的。结果表明，在实际中普遍接受的关于正态分布模式的假设，可能会导致定量评估中出现明显误差，并得出错误的定性结论。金属的最可能浓度及其分布宽度随时间变化，不同金属的变化不同，包括极值变化，被测金属的浓度变化1至5倍，元素间关系变化高达10倍。对于钾-钠、铁-锰、锌-铜和铁-铜对，发现了可能具有生化性质的元素间关系，这些关系的稳定性取决于哺乳期。生物金属平衡变化的数据可用于设计更适合不同年龄婴儿的母乳和配方奶替代品。
