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[高肌红蛋白血症和肌酸磷酸激酶MB活性作为心肌合并损伤及急性脑循环障碍的体征]

[Hypermyoglobinemia and creatine phosphokinase MB activity as signs of combined myocardial lesion and acute cerebral circulatory disorder].

作者信息

Gabashvili V M, Kipiani M K, Kurashvili R B

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(11):1617-21.

PMID:4082828
Abstract

In order to detect simultaneous damage to the myocardium in cerebral stroke the authors radioimmunoassayed myoglubin and activity of the heart fraction of creatine phosphokinase MB (CP K MB) in the blood serum of 22 patients. Hypermyoglobinemia and elevated activity of CP K MB were revealed in almost all cases of hemorrhagic stroke (15 patients) whereas in patients with ischemic stroke they were identified far less frequently. Thus, hypermyoglobinemia and the activity of CP K MB correlate with the macro- and microscopic picture of myocardial damage and may serve as its diagnostic criteria when both the clinical picture and ECG findings prove uninformative.

摘要

为了检测脑卒中患者是否同时存在心肌损伤,作者对22例患者血清中的肌红蛋白以及肌酸磷酸激酶同工酶MB(CPK MB)的心脏活性进行了放射免疫测定。几乎所有出血性脑卒中患者(15例)均出现高肌红蛋白血症和CPK MB活性升高,而缺血性脑卒中患者出现的频率则低得多。因此,高肌红蛋白血症和CPK MB活性与心肌损伤的大体和微观表现相关,当临床表现和心电图检查结果均无诊断价值时,它们可作为心肌损伤的诊断标准。

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