Told Reinhard, Reumueller Adrian, Kreminger Judith, Sacu Stefan, Dunavoelgyi Roman
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
PLoS One. 2025 Aug 19;20(8):e0328360. doi: 10.1371/journal.pone.0328360. eCollection 2025.
To characterize patients with choroidal or ciliary body (CB) melanoma in order to identify factors associated with time until metastasis and further perform a detailed characterization of the factors identified.
A mixed model approach was used to identify parameters and patient characteristics associated with time until metastatic event. Consequently, the identified parameters were characterized.
In 383 patients with primary choroidal and CB melanoma, tumor thickness and patient age at diagnosis are associated with time until metastatic event. Mean patient age was 61 ± 13 years, mean choroidal and CB melanoma thickness was 5.1 ± 1.9 mm. Other factors investigated comprising sex, primary tumor width, length, volume, shape, and type of therapy are not associated with time until metastatic event in this patient collective.
In conclusion, this study expands the current knowledge on factors associated with metastasis due to primary choroidal or CB melanoma. So far primary choroidal or CB melanoma thickness has been shown to be a risk indicator for metastatic events. Now, we could show that primary choroidal or CB melanoma thickness is also correlated with time until metastatic event. The association can be expressed as: the thicker the primary tumor, the earlier the potential metastatic event. Age may be considered an indirect effect in the model calculated.
对脉络膜或睫状体（CB）黑色素瘤患者进行特征分析，以确定与转移发生时间相关的因素，并进一步对所确定的因素进行详细特征描述。
采用混合模型方法来确定与转移事件发生时间相关的参数和患者特征。随后，对所确定的参数进行特征描述。
在383例原发性脉络膜和CB黑色素瘤患者中，肿瘤厚度和诊断时的患者年龄与转移事件发生时间相关。患者平均年龄为61±13岁，脉络膜和CB黑色素瘤平均厚度为5.1±1.9毫米。在该患者群体中，所研究的其他因素，包括性别、原发性肿瘤宽度、长度、体积、形状和治疗类型，与转移事件发生时间无关。
总之，本研究扩展了目前关于原发性脉络膜或CB黑色素瘤相关转移因素的知识。到目前为止，原发性脉络膜或CB黑色素瘤厚度已被证明是转移事件的一个风险指标。现在，我们可以表明原发性脉络膜或CB黑色素瘤厚度也与转移事件发生时间相关。这种关联可以表示为：原发性肿瘤越厚，潜在转移事件发生越早。在计算的模型中，年龄可能被视为一种间接影响因素。
