Barcs I
Acta Microbiol Hung. 1985;32(3):241-8.
Localization and genetic nature of inducible macrolide resistance determinants in some coagulase negative staphylococci (CNS) were studied and compared with those in Staphylococcus aureus. An 1.7-megadalton R-plasmid, pEI 1107, mediating inducible resistance to macrolides and lincosamides was present in part of Staphylococcus simulans and Staphylococcus epidermidis strains isolated in the Central Hospital for Infectious Diseases. Two other plasmids were harboured by S. simulans LK 6108 strain. One of these plasmids, pEI 6108 (molecular mass 5.2 Md) was encoded for inducible macrolide-lincosamide resistance, and the second one, pE 6108 (molecular mass 4.9 Md) for constitutive marcolide resistance. The similarity in size and phenotype of small plasmids in CNS and S. aureus suggest a common origin of these resistance determinants.
对一些凝固酶阴性葡萄球菌（CNS）中可诱导大环内酯类耐药决定簇的定位和遗传特性进行了研究，并与金黄色葡萄球菌中的进行了比较。在传染病中心医院分离的部分模仿葡萄球菌和表皮葡萄球菌菌株中，存在一个1.7兆道尔顿的R质粒pEI 1107，它介导对大环内酯类和林可酰胺类的诱导性耐药。模仿葡萄球菌LK 6108菌株携带另外两个质粒。其中一个质粒pEI 6108（分子量5.2 Md）编码可诱导的大环内酯-林可酰胺耐药性，另一个质粒pE 6108（分子量4.9 Md）编码组成型大环内酯耐药性。CNS和金黄色葡萄球菌中小质粒在大小和表型上的相似性表明这些耐药决定簇有共同的起源。
