Quigley H A, Davis E B, Anderson D R
Invest Ophthalmol Vis Sci. 1977 Sep;16(9):841-9.
We cut the optic nerve at the orbital apex in squirrel monkeys to study the descending degeneration of optic nerve axons and their ganglion cell bodies. We could not detect progressive disintegration of the axon from the site of injury back to the cell body. Instead, the entire length of individual axons seemed to degenerate simultaneously as early as 3 weeks and as late as 6 weeks after injury, as judged both by ultrastructural integrity and by continued slow axonal transport, a reflection of local physiologic function. We could not relate the time of degeneration to the distance of the injury from the cell body. Evidently there is a signal of injury to the cell body after axotomy, though the nature of the signal and the mechanism by which it leads to cell death are unknown.
我们切断松鼠猴眶尖处的视神经，以研究视神经轴突及其神经节细胞体的下行性变性。我们无法检测到轴突从损伤部位向细胞体方向的渐进性崩解。相反，早在损伤后3周，最晚在损伤后6周，通过超微结构完整性和持续缓慢的轴突运输（反映局部生理功能）判断，单个轴突的全长似乎同时发生变性。我们无法将变性时间与损伤部位距细胞体的距离联系起来。显然，轴突切断术后存在向细胞体传递损伤的信号，尽管该信号的性质及其导致细胞死亡的机制尚不清楚。
