Iivanainen M, Laaksonen R, Niemi M L, Färkkilä M, Bergström L, Mattson K, Niiranen A, Cantell K
Acta Neurol Scand. 1985 Nov;72(5):475-80. doi: 10.1111/j.1600-0404.1985.tb00904.x.
Patients with amyotrophic lateral sclerosis were treated with high-dose intravenous infusion of human leukocyte interferon for six days. Neuropsychological examinations were carried out before, during and after the treatment. Marked reversible dysfunction was detected in immediate memory functions, coordination of hand movements, and drawing. Motor perseveration, micrographia, and slowing of behaviour were also observed. Changes appeared four to 12 days after start of treatment, with the peak on days six to eight. Recovery was almost complete by day 15. Intellectual ability, as measured by three WAIS subtests, praxis of hand movements, visuognostic functions, speech, reading, writing, and calculation remained essentially unaffected. The profile of the neuropsychological deficits observed, the absence of defects typical of focal posterior cortical lesions, the simultaneously slowed electroencephalographic activity with frontal accentuation, and the increased central conduction times of brain stem auditory evoked potentials suggest frontobasal involvement.
肌萎缩侧索硬化症患者接受了大剂量静脉输注人白细胞干扰素治疗，为期六天。在治疗前、治疗期间和治疗后进行了神经心理学检查。在即刻记忆功能、手部运动协调性和绘图方面检测到明显的可逆性功能障碍。还观察到运动持续性、小字症和行为迟缓。治疗开始后4至12天出现变化，在第6至8天达到高峰。到第15天恢复几乎完全。通过韦氏成人智力量表的三个分测验测量的智力能力、手部运动实践、视觉认知功能、言语、阅读、写作和计算基本上未受影响。所观察到的神经心理学缺陷的特征、缺乏典型的局灶性后皮质病变缺陷、脑电图活动同时减慢且额叶明显以及脑干听觉诱发电位的中枢传导时间增加提示额基底受累。
