Adams F, Fernandez F, Mavligit G
Division of Medicine, University of Texas, M.D. Anderson Hospital and Tumor Institute, Houston.
J Neurooncol. 1988 Dec;6(4):355-9. doi: 10.1007/BF00177432.
Eleven patients ranging in age from 52 to 80 years, undergoing treatment for cancer with various preparations of interferon received neurobehavioral evaluations after experiencing unexpectedly severe organic mental disorders. The reactions ranged from delirium to extrapyramidal symptoms, mania, and neurasthenia with catatonic episodes. Computed tomographic (CT) scans of the brain disclosed unsuspected pre-existing neurologic abnormalities in all patients, including cerebral atrophy (6/11), brain metastases (4/11), and evidence of head injury incurred 40 years earlier (1/11). These findings suggest that cancer patients with pre-existing neurologic dysfunctions are at increased risk for severe interferon neurotoxicity.
11名年龄在52岁至80岁之间的癌症患者，在使用各种干扰素制剂进行癌症治疗后，出现了意外严重的器质性精神障碍，随后接受了神经行为评估。这些反应包括谵妄、锥体外系症状、躁狂和伴有紧张症发作的神经衰弱。脑部计算机断层扫描（CT）显示，所有患者均存在先前未被怀疑的神经学异常，包括脑萎缩（6/11）、脑转移瘤（4/11）以及40年前头部受伤的证据（1/11）。这些发现表明，已有神经功能障碍的癌症患者发生严重干扰素神经毒性的风险增加。
