高剂量干扰素在肌萎缩侧索硬化症中的神经毒性及其他副作用。

Neurotoxic and other side effects of high-dose interferon in amyotrophic lateral sclerosis.

作者信息

Färkkilä M, Iivanainen M, Roine R, Bergström L, Laaksonen R, Niemi M L, Cantell K

出版信息

Acta Neurol Scand. 1984 Jul;70(1):42-6. doi: 10.1111/j.1600-0404.1984.tb00801.x.

DOI:10.1111/j.1600-0404.1984.tb00801.x

PMID:6206681

Abstract

6 patients with amyotrophic lateral sclerosis were treated with intravenous infusion of 100-200 million IU per day of human leukocyte interferon. Side effects of treatment included fever, chills, malaise, nausea, marked leukopenia, mild anemia, and thrombocytopenia. Tiredness, confusion, papilledema, and overall signs of acute encephalitis were observed. Tendon reflexes and muscle force decreased. EEG activity was slowed, and evoked potentials showed significant slowing of conduction times. Neuropsychological tests revealed congitive dysfunction. The syndrome of inappropriate antidiuretic hormone secretion developed in all patients. All side effects were reversible with cessation of interferon treatment.

摘要

6例肌萎缩侧索硬化症患者接受了每天静脉输注1亿至2亿国际单位人白细胞干扰素的治疗。治疗的副作用包括发热、寒战、不适、恶心、明显的白细胞减少、轻度贫血和血小板减少。观察到疲倦、意识模糊、视乳头水肿和急性脑炎的总体体征。腱反射和肌力下降。脑电图活动减慢，诱发电位显示传导时间明显减慢。神经心理学测试显示存在认知功能障碍。所有患者均出现抗利尿激素分泌不当综合征。停止干扰素治疗后，所有副作用均可逆转。