Fräki J E, Kalimo K, Tuohimaa P, Aantaa E
Acta Otolaryngol. 1985 Nov-Dec;100(5-6):414-8. doi: 10.3109/00016488509126565.
Patients suffering from chronic external otitis had developed contact allergies to one or more compounds of topical preparations in 40% of 142 tested patients. Neomycin and framycetin caused most of the allergic reactions (16.2%) followed by chinoform (7.0%), chloramphenicol and polymyxin (4.2%). Preservatives of the topical otic preparations such as benzethonium chloride (8.5%), benzalkonium chloride (6.3%) and thimerosal (merthiolate) (5.6%) were also common causes of allergic reactions. An epicutaneous test (patch test) using compounds in topical preparations should be done in cases of prolonged, treatment resistant external otitis.
在142例接受检测的慢性外耳炎患者中，40%对一种或多种局部用制剂的化合物产生了接触性过敏。新霉素和硫酸新霉素引起的过敏反应最多（16.2%），其次是氯碘喹啉（7.0%）、氯霉素和多粘菌素（4.2%）。局部耳用制剂的防腐剂，如氯化苄乙铵（8.5%）、苯扎氯铵（6.3%）和硫柳汞（5.6%）也是过敏反应的常见原因。对于持续性、治疗抵抗性外耳炎病例，应使用局部用制剂中的化合物进行皮肤试验（斑贴试验）。
