Fräki J E, Peltonen L, Hopsu-Havu V K
Contact Dermatitis. 1979 Mar;5(2):97-100. doi: 10.1111/j.1600-0536.1979.tb04806.x.
Patients suffering from stasis dermatitis and leg ulcers (192) were found to give an allergic reaction in epicutaneous tests to one or more components of topical preparations in 69.2% of cases. The most common reactions were obtained with neomycin 34.0% and its component framycetin 31.2%, wool alcohols 22.9%, balsam of Peru 21.4%, chlorquinaldon 16.7%, bacitracin 13.1%, chinoform 10.9%, dequalin 9.9%, formaldehyde 4.2% and parabens 3.6%. The incidence of allergic reactions reflects local use of preparations containing various allergens as well as their capacity to produce alllergy. Allergy may in some cases interfere with effective topical therapy. Debrisan dextran polymer beads were found to be suitable for treatment of ulcers of multiallergic patients without risk of contact allergy.
患有淤积性皮炎和腿部溃疡的患者（192例）经皮试发现，69.2%的病例对局部制剂的一种或多种成分有过敏反应。最常见的反应是对新霉素（34.0%）及其成分硫酸新霉素（31.2%）、羊毛醇（22.9%）、秘鲁香脂（21.4%）、氯喹那多（16.7%）、杆菌肽（13.1%）、氯碘喹啉（10.9%）、地喹氯铵（9.9%）、甲醛（4.2%）和对羟基苯甲酸酯（3.6%）。过敏反应的发生率反映了含有各种过敏原的制剂的局部使用情况及其产生过敏的能力。在某些情况下，过敏可能会干扰有效的局部治疗。发现Debrisan葡聚糖聚合物珠适用于治疗多重过敏患者的溃疡，且无接触过敏风险。
