Sirikulchayanonta V, Sriurairatna S
Acta Pathol Jpn. 1985 Sep;35(5):1233-9.
A 50-year-old male developed a sacro-coccygeal chordoma. Prior to the surgery, he had experienced back-pain, numbness of the right thigh and difficulty in voiding and defecation. Total excision of the mass was done and all symptoms were relieved. The light microscopic examination revealed a chordoma. The ultrastructural study was performed with particular interest in physaliferous cells. The fine structure disclosed the prominent associations of mitochondria and rough endoplasmic reticulum. The mitochondria showed irregularities in sizes and shapes but did not attenuate as much as previously reported. The vacuoles that were observed by light microscopy in physaliferous cells were both extra-cellular and intra-cellular and contained finely granular material of acid mucopolysaccharides probably of chondroitin type. The presence of both subplasmalemmal linear densities (SLD) and pinocytic vesicles was consistent with the histogenetic conviction that the tumor arose from mesodermal derivatives.
一名50岁男性患骶尾部脊索瘤。手术前，他曾经历背痛、右大腿麻木以及排尿和排便困难。对肿块进行了全切除，所有症状均得到缓解。光镜检查显示为脊索瘤。进行了超微结构研究，特别关注泡沫细胞。精细结构显示线粒体与粗面内质网有明显关联。线粒体大小和形状不规则，但不像先前报道的那样明显萎缩。光镜下在泡沫细胞中观察到的空泡存在于细胞外和细胞内，含有可能为软骨素类型的酸性粘多糖细颗粒物质。质膜下线性密度（SLD）和胞饮小泡的存在与肿瘤起源于中胚层衍生物的组织发生学观点一致。
