一种基于狂犬病的高致病性甲型H5流感病毒疫苗在牛体内的免疫原性和安全性

Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle.

作者信息

Paran Nir, Wirblich Christoph, Olal Catherine, Tarquinio Alessandro, Lohmeyer Kimberly H, Kurup Drishya, Schultz-Cherry Stacey, Shittu Ismaila, Gray Gregory C, Bente Dennis A, Olafson Pia U, Schnell Matthias J

机构信息

Department of Microbiology and Immunology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Jefferson Center for Vaccines and Pandemic Preparedness, Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

NPJ Vaccines. 2025 Aug 19;10(1):197. doi: 10.1038/s41541-025-01238-2.

DOI:10.1038/s41541-025-01238-2

PMID:40830096

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12365278/

Abstract

The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.

摘要

高致病性甲型H5流感病毒在牛、其他哺乳动物和野生动物中的传播威胁着动物和人类健康。为应对这一问题，我们用一种基于灭活狂犬病病毒的H5疫苗对小母牛犊进行了接种，该疫苗耐受性良好，能引发针对1系和2.3.4.4b系H5N1病毒的中和抗体，与自然感染H5并正在康复的母牛相当。对该疫苗平台的免疫反应至少持续200天，且不受先前狂犬病病毒免疫的影响。