Roubidoux Ericka Kirkpatrick, Meliopoulos Victoria, Livingston Brandi, Brigleb Pamela H, Schultz-Cherry Stacey
bioRxiv. 2024 Nov 2:2024.11.01.621606. doi: 10.1101/2024.11.01.621606.
The ongoing outbreak of highly pathogenic avian influenza (HPAI) H5N1 of the clade 2.3.4.4b in dairy cows has led to numerous questions including how the virus transmits amongst cattle given the limited respiratory infection. One hypothesis is that the virus is spreading through fomites from udder to udder. In these studies, we demonstrate that intraductal inoculation of H5N1 but not H1N1 influenza virus results in infection in mice. This model will be useful to our understanding of the impact of influenza virus on the mammary gland, the potential as a new route of transmission, and can be used to assess if antiviral treatments prevent infections in the mammary gland.
2.3.4.4b分支的高致病性禽流感（HPAI）H5N1在奶牛中持续爆发引发了诸多问题，其中包括鉴于呼吸道感染有限，该病毒如何在牛群中传播。一种假说认为，病毒是通过 fomites 从一个乳房传播到另一个乳房。在这些研究中，我们证明，经导管接种H5N1流感病毒而非H1N1流感病毒会导致小鼠感染。该模型将有助于我们了解流感病毒对乳腺的影响、作为一种新传播途径的可能性，并且可用于评估抗病毒治疗是否能预防乳腺感染。
