Wu Lei, He Hongxin, Liang Tingting, Du Guowei, Li Longyan, Zhong Haojie, Li Ying, Zhang Jinke, Chen Ning, Jiang Tong, Yang Juan, Wang Jiangyan, Feng Shuo, Lu Shenghua, Zhao Hui, Gu Qihui, Gao He, Li Guanghui, Xie Wenrui, Wu Lihao, Wu Qingping, Xie Xinqiang, He Xingxiang
Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
NPJ Biofilms Microbiomes. 2025 Aug 19;11(1):165. doi: 10.1038/s41522-025-00812-9.
The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We performed a cross-sectional study of 224 people from Jiaoling, China, which is globally recognised for the longevity of its residents. Compared with younger people, centenarians showed significantly increased alpha-diversity, enrichment of the beneficial bacteria Lactobacillus, Akkermansia, and Christensenella, and increased redox capacity in the gut microbiota. Serum metabolomics of centenarians showed significant enrichment of antioxidant metabolites, including L-ascorbic acid 2-sulphate and lipoic acid. Finally, we isolated and screened a strain of Lactobacillus plantarum 124 (LP124) with a good antioxidant effect on the gut microbiota of centenarians. Animal experiments further verified that mesaconic acid from LP124 regulates the gut microbiota, is anti-inflammatory, relieves oxidative stress, maintains the intestinal barrier, and is the best-known anti-aging molecule. LP124 derived from the gut microbiota of centenarians and its metabolite mesaconic acid, have a significant positive effect on health and longevity.
百岁老人的肠道微生物群在促进健康长寿方面起着至关重要的作用。我们对来自中国蕉岭的224人进行了一项横断面研究，该地因其居民的长寿而在全球闻名。与年轻人相比，百岁老人的肠道微生物群显示出α多样性显著增加、有益细菌乳酸杆菌属、阿克曼氏菌属和克里斯滕森菌属富集，以及氧化还原能力增强。百岁老人的血清代谢组学显示抗氧化代谢物显著富集，包括L-抗坏血酸2-硫酸盐和硫辛酸。最后，我们分离并筛选出了一株对百岁老人肠道微生物群具有良好抗氧化作用的植物乳杆菌124（LP124）。动物实验进一步证实，LP124产生的甲基丙烯酸可调节肠道微生物群，具有抗炎作用，减轻氧化应激，维持肠道屏障，是最著名的抗衰老分子。源自百岁老人肠道微生物群的LP124及其代谢产物甲基丙烯酸对健康和长寿具有显著积极影响。
