Hede A R, Andersson L, Post C
Acta Pharmacol Toxicol (Copenh). 1985 Oct;57(4):291-6. doi: 10.1111/j.1600-0773.1985.tb00045.x.
The potency of halogenated methanes to inhibit uptake of 5-hydroxytryptamine (5-HT) from the pulmonary circulation was studied using an isolated, perfused and ventilated rat lung preparation. The agents were vaporized and mixed with the inlet air. The results indicate that the degree of chlorination is the most important factor for potency of the methanes to inhibit lung uptake of 5-HT. When hydrogen was substituted with fluorine the potency was decreased dramatically. Bromine seemed to have the opposite effect. The data also suggested that the degree of chlorination was more important rather than hydrophobic/hydrophilic balance of the solvent molecule. These effects seem to be correlated with the narcotic effects of the substances studied.
使用离体、灌注和通气的大鼠肺制备物，研究了卤代甲烷抑制5-羟色胺（5-HT）从肺循环摄取的能力。将这些试剂汽化并与进气混合。结果表明，氯化程度是甲烷抑制肺摄取5-HT能力的最重要因素。当氢被氟取代时，其能力显著降低。溴似乎有相反的效果。数据还表明，氯化程度比溶剂分子的疏水/亲水平衡更重要。这些效应似乎与所研究物质的麻醉作用相关。
