Fleming Anita, Provenza Fred D, Leroy Frédéric, van Vliet Stephan, Elliot Catherine, Hamlin Michael, Garrett Konagh, Marshall Cameron Joel, Gregorini Pablo
Department of Agriculture and Life Sciences, Lincoln University, Lincoln, Christchurch, New Zealand.
Department of Wildland Resources, Utah State University, Logan, UT.
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf254.
Emerging evidence suggests that the metabolites present in biochemically diverse herbages cascade across trophic levels, influencing both the meat quality of grazing cattle and human metabolomic profiles. This study compared the metabolomic profiles of Angus cattle finished on three distinct pasture systems: a standard perennial ryegrass and white clover sward (PRG), a complex multispecies mixture (CMS; n = 22 species), and adjacent monoculture strips (AMS) comprising ryegrass, chicory, plantain, lucerne, and red clover in equal areas. The resulting tenderloins were processed into (250 g) beef patties and assessed in a double-blind, randomized, crossover clinical trial involving 23 human participants (ANZCTR registration: ACTRN12624001081505). The AMS herbage contained higher concentrations of gamma-tocopherol (vitamin E) and eicosapentaenoic acid (EPA), which were reflected in elevated levels of these compounds in the beef (P < 0.05) and, subsequently, in human plasma 3 to 5 h postprandial (P < 0.05). These results are the first to demonstrate that human metabolomic responses are directly influenced by the forage composition of grazing cattle, highlighting a novel linkage between pastoral diversity, animal diet, and consumer health outcomes.
新出现的证据表明，生物化学组成多样的牧草中存在的代谢物会在营养级间层层传递，影响放牧牛的肉质和人类代谢组学特征。本研究比较了在三种不同牧场系统中育肥的安格斯牛的代谢组学特征：标准多年生黑麦草和白三叶草草地（PRG）、复杂多物种混合草地（CMS；n = 22种）以及由黑麦草、菊苣、车前草、苜蓿和红三叶草等面积组成的相邻单一栽培带（AMS）。将所得牛里脊加工成（250克）牛肉饼，并在一项涉及23名人类参与者的双盲、随机、交叉临床试验中进行评估（澳大利亚和新西兰临床试验注册中心注册号：ACTRN12624001081505）。AMS牧草中γ-生育酚（维生素E）和二十碳五烯酸（EPA）的浓度较高，牛肉中这些化合物的含量升高体现了这一点（P < 0.05），随后，在餐后3至5小时的人体血浆中也出现了这种情况（P < 0.05）。这些结果首次表明，人类代谢组学反应直接受到放牧牛的饲料组成的影响，突出了牧区多样性、动物饮食和消费者健康结果之间的新联系。
