Dike Nkechi Oluwakemi, Blankson Emmanuel S, Segnitome Sarah
School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Emergency Department, Upper West Regional Hospital, Wa, Ghana.
Int Med Case Rep J. 2025 Aug 14;18:1035-1040. doi: 10.2147/IMCRJ.S534544. eCollection 2025.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a sex-linked chromosomal disorder, is the most common enzymopathy in humans. This enzyme, which protects red blood cells, when deficient, predisposes individuals to hemolysis under oxidative stress. Several chemicals and drugs have been commonly known to cause hemolysis in G6PD deficiency. However, an uncommon substance, henna, a plant-based dye used in Africa and Asia, has also been described to trigger hemolysis in G6PD-deficient individuals. It shares similarities in the structural ring and properties with other well-described G6PD hemolytic agents. We present a rare case of severe intravascular hemolysis following topical henna application in an 8-year-old girl with G6PD deficiency, successfully managed at the Upper West Regional Hospital in Ghana.
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是一种X连锁染色体疾病，是人类最常见的酶病。这种保护红细胞的酶缺乏时，会使个体在氧化应激下易发生溶血。众所周知，几种化学物质和药物会在G6PD缺乏症患者中引起溶血。然而，一种不常见的物质——指甲花，一种在非洲和亚洲使用的植物染料，也被描述为可在G6PD缺乏症患者中引发溶血。它在结构环和性质上与其他已明确的G6PD溶血剂相似。我们报告了一例罕见病例，一名8岁G6PD缺乏症女童在局部应用指甲花后发生严重血管内溶血，在加纳上西部地区医院成功治愈。
