Taleb Mariem, Brahim Aminetou Taleb, Yebouk Cheikh, Khairy T'feila, Ishagh Beybeti, Lyoussi Badiaa, Ghaber Sidi Mohamed
Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health, and Quality of Life (SNAMOPEQ), Department of Biology, Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdallah, 30000 Fez, Morocco.
Department of Molecular Research, Maurilab Medical Analysis and Research Institute, 2434 Nouakchott, Mauritania.
Pan Afr Med J. 2025 Jan 6;50:7. doi: 10.11604/pamj.2025.50.7.45066. eCollection 2025.
it is now clear that several antimalarials, such as primaquine, can cause severe hemolytic anemia in people with G6PD deficiency. Prescriptions for antimalarials should consider G6PD status, especially in malaria-endemic areas. The frequency of G6PD is quite high in some countries in sub-Saharan Africa.
a systematic review was conducted to summarize the findings on the G6PD deficiency epidemiology in the ten African nations most impacted by malaria. We conducted a systematic electronic literature search based on eligibility requirements using databases, PubMed, Google Scholar, and ScienceDirect. The chosen studies are original or primary studies published in English or French and evaluate the prevalence of G6PD deficiency or its incidence, in a peer-reviewed scientific journal during the interval of time 2000-2023 were included in this review. The systematic review was carried out by using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).
after being screened, 19 complete texts were deemed appropriate for extracting data. The prevalence of G6PD deficiency varied among these ten African countries, ranging from <1% to 23.9%, with a considerable dominance when it comes to men in comparison with women.
to avoid morbidity and mortality among the population in the affected areas, several regions in African countries must review their diagnostic and screening protocols to detect deficiency in G6PD to make proper interventions in time.
现在很清楚，几种抗疟药，如伯氨喹，可导致葡萄糖-6-磷酸脱氢酶（G6PD）缺乏者发生严重溶血性贫血。抗疟药的处方应考虑G6PD状态，特别是在疟疾流行地区。G6PD缺乏在撒哈拉以南非洲的一些国家发病率相当高。
进行了一项系统评价，以总结在受疟疾影响最严重的十个非洲国家中G6PD缺乏症流行病学的研究结果。我们根据纳入标准，使用数据库、PubMed、谷歌学术和科学Direct进行了系统的电子文献检索。所选研究为发表于英文或法文的原创性或基础性研究，并在2000年至2023年期间在同行评审的科学期刊上评估了G6PD缺乏症的患病率或发病率，本次评价纳入了这些研究。系统评价采用PRISMA（系统评价和Meta分析的首选报告项目）进行。
经过筛选，19篇全文被认为适合提取数据。这十个非洲国家中G6PD缺乏症的患病率各不相同，范围从<1%到23.9%，男性患病率明显高于女性。
为避免受影响地区人群发病和死亡，非洲国家的一些地区必须审查其诊断和筛查方案，以检测G6PD缺乏症，以便及时进行适当干预。
