Ai Lin, Cui Xinyi, Zhou Yanqiu
Institute of Microbiology Laboratory, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Shanghai Academy of Preventive Medicine, Shanghai, China.
China CDC Wkly. 2025 Jul 18;7(29):979-984. doi: 10.46234/ccdcw2025.165.
In recent years, mpox virus Clade Ib has emerged as a significant global public health threat due to its rapid transmission and potential for severe disease outcomes. This strain was first identified in the Democratic Republic of the Congo (DRC) in September 2023 and began spreading to neighboring African countries by July 2024. It was subsequently imported through international travel to 12 non-African countries across Asia, Europe, and the Americas. Clade Ib exhibits increased transmissibility, and current data suggest that infections may lead to more severe symptoms, with higher risks of severe illness and mortality, particularly among vulnerable populations such as children, pregnant individuals, and immunocompromised groups (e.g., people living with HIV/AIDS). Epidemiologically, Clade Ib primarily spreads through sexual contact, close household contact, and healthcare-related exposure. This review aims to provide an overview of the current understanding of mpox virus Clade Ib, including its genetic characteristics, epidemiological patterns, and prevention and control strategies. Additionally, it discusses the strategies and interventions needed to address this emerging threat.
近年来，猴痘病毒Ib分支因其快速传播和导致严重疾病后果的可能性，已成为全球重大公共卫生威胁。该毒株于2023年9月在刚果民主共和国首次被发现，并于2024年7月开始传播至非洲邻国。随后，它通过国际旅行传入亚洲、欧洲和美洲的12个非非洲国家。Ib分支的传播性增强，目前的数据表明感染可能导致更严重的症状，患重病和死亡的风险更高，尤其是在儿童、孕妇和免疫功能低下群体（如感染艾滋病毒/艾滋病者）等弱势群体中。在流行病学上，Ib分支主要通过性接触、家庭密切接触和医疗相关暴露传播。本综述旨在概述目前对猴痘病毒Ib分支的认识，包括其基因特征、流行病学模式以及预防和控制策略。此外，还讨论了应对这一新兴威胁所需的策略和干预措施。
