Stanley W C, Gertz E W, Wisneski J A, Morris D L, Neese R A, Brooks G A
Am J Physiol. 1985 Dec;249(6 Pt 1):E595-602. doi: 10.1152/ajpendo.1985.249.6.E595.
To investigate the relationships between oxygen consumption (VO2) and the rates of systemic lactate appearance (Ra) and disappearance (Rd), six healthy males were studied at rest and during continuous graded exercise using a primed continuous infusion of lactate tracer. Subjects exercised for 6 min at 300, 600, 900, and 1,200 kg . m . min-1. L-(+)-[1-14C]lactate was infused intravenously, and arterial samples were drawn at rest and every 2 min throughout the exercise period. Ra and Rd were calculated using nonsteady-state equations. At rest Ra and Rd were 14.4 +/- 1.8 and 15.1 +/- 2.2 mumol . kg-1 . min-1, respectively. Near steady-state values were observed toward the end of the first two work loads. Ra and Rd values were 32.8 +/- 2.3 and 37.4 +/- 1.3 mumol . kg-1 . min-1 during min 5 and 6 at 300 kg . m . min-1 and were 59.1 +/- 2.6 and 55.4 +/- 2.3 mumol . kg-1 . min-1 during min 5 and 6 at 600 kg . m . min-1. Ra was significantly greater than Rd at both 900 and 1,200 kg . m . min-1. Ra and Rd averaged 145.4 +/- 10.5 and 110.2 +/- 5.6 mumol . kg-1 . min-1, respectively, during the last 2 min at 900 kg . m . min-1, and 309.4 +/- 20.8 and 169.7 +/- 10.6 mumol . kg-1 . min-1, respectively, at 1,200 kg . m . min-1.(ABSTRACT TRUNCATED AT 250 WORDS)
为了研究耗氧量（VO2）与全身乳酸生成率（Ra）和消失率（Rd）之间的关系，对6名健康男性在静息状态以及使用乳酸示踪剂进行连续递增运动期间进行了研究。受试者在300、600、900和1200千克·米·分钟-1的强度下各运动6分钟。静脉输注L-(+)-[1-14C]乳酸，并在静息状态以及运动期间每隔2分钟采集动脉血样。使用非稳态方程计算Ra和Rd。静息时，Ra和Rd分别为14.4±1.8和15.1±2.2微摩尔·千克-1·分钟-1。在前两个工作负荷接近结束时观察到接近稳态的值。在300千克·米·分钟-1的第5和6分钟期间，Ra和Rd值分别为32.8±2.3和37.4±1.3微摩尔·千克-1·分钟-1；在600千克·米·分钟-1的第5和6分钟期间，分别为59.1±2.6和55.4±2.3微摩尔·千克-1·分钟-1。在900和1200千克·米·分钟-1时，Ra均显著大于Rd。在900千克·米·分钟-1的最后2分钟期间，Ra和Rd的平均值分别为145.4±10.5和110.2±5.6微摩尔·千克-1·分钟-1；在1200千克·米·分钟-1时，分别为309.4±20.8和169.7±10.6微摩尔·千克-1·分钟-1。（摘要截断于250字）
