Asghar Muhammad Umer, Ain Noor Ul, Tariq Muhammad, Zaidi Arsalan Haseeb
National Probiotic Lab, National Institute for Biotechnology and Genetic Engineering-College (NIBGE-C), Faisalabad, 38000, Pakistan.
Pakistan Institute of Engineering & Applied Sciences (PIEAS), Nilore Islamabad (ICT), 45650, Pakistan.
Probiotics Antimicrob Proteins. 2025 Aug 20. doi: 10.1007/s12602-025-10722-z.
The global burden of antimicrobial resistance (AMR) and healthcare-associated infections (HAIs) is exacerbated by an increase in the number of biocide-resistant pathogens in hospital settings. Traditional disinfection methods face limitations, such as biofilm resilience, environmental hazards, and inadvertent selection of resistant strains. This review explores peptide-based disinfectants as innovative solutions to these challenges and highlights their broad-spectrum antimicrobial activity, biodegradability, and eco-friendliness. Antimicrobial peptides (AMPs) exhibit mechanisms such as membrane disruption, biofilm inhibition, and bridging the gap between conventional and probiotic disinfectants. Innovations in peptide design and bioengineering have enhanced their efficacy against multidrug-resistant pathogens, including vancomycin-resistant Staphylococcus aureus and carbapenem-resistant Enterobacteriaceae (CRE). AMP-based solutions have shown a 70-90% reduction in pathogen load in hospital trials, surpassing traditional disinfectants in terms of both effectiveness and safety. This review also emphasizes the feasibility of AMP-based disinfectants in resource-limited settings, where AMR and biocide resistance are particularly problematic. By analyzing the challenges, innovations, and economic aspects of integrating peptide-based disinfectants into hospital hygiene protocols, this study underscores their transformative potential. AMP-based solutions offer sustainable alternatives to combat AMR and biocide resistance, paving the way for more effective global infection-control strategies.
医院环境中抗微生物剂耐药性（AMR）病原体数量的增加以及医疗保健相关感染（HAIs），加剧了全球抗微生物剂耐药性和医疗保健相关感染的负担。传统消毒方法面临诸多限制，如生物膜弹性、环境危害以及无意间选择耐药菌株等问题。本综述探讨了基于肽的消毒剂，将其作为应对这些挑战的创新解决方案，并强调了它们的广谱抗菌活性、生物可降解性和生态友好性。抗菌肽（AMPs）具有诸如破坏细胞膜、抑制生物膜以及弥合传统消毒剂与益生菌消毒剂之间差距等作用机制。肽设计和生物工程方面的创新提高了它们对多重耐药病原体的效力，这些病原体包括耐万古霉素金黄色葡萄球菌和耐碳青霉烯类肠杆菌科细菌（CRE）。在医院试验中，基于AMP的解决方案已使病原体载量降低了70%至90%，在有效性和安全性方面均超过了传统消毒剂。本综述还强调了基于AMP的消毒剂在资源有限环境中的可行性，在这些环境中，抗微生物剂耐药性和抗微生物剂耐药性问题尤为突出。通过分析将基于肽的消毒剂纳入医院卫生规程所面临的挑战、创新和经济方面，本研究强调了它们的变革潜力。基于AMP的解决方案为对抗抗微生物剂耐药性和抗微生物剂耐药性提供了可持续的替代方案，为更有效的全球感染控制策略铺平了道路。
