Villagelin Danilo, Perini Nicolas, Santos Roberto Bernardo, Romaldini João Hamilton
Pontifícia Universidade Católica de Campinas Escola de Ciências da Vida Faculdade de Medicina Campinas SP Brasil Pontifícia Universidade Católica de Campinas, Escola de Ciências da Vida, Faculdade de Medicina, Campinas, SP, Brasil.
Universidade Estadual de Campinas Campinas SP Brasil Universidade Estadual de Campinas, Pós-graduação em Medicina Interna, Campinas, SP, Brasil.
Arch Endocrinol Metab. 2025 Aug 20;69(3):e240495. doi: 10.20945/2359-4292-2024-0495.
Graves' disease (GD) is the leading cause of hyperthyroidism globally, with 40% of affected individuals developing thyroid eye disease (TED). Treatment options for TED have advanced in recent years. This study aimed to investigate the prevalence of TED at a single center in Brazil, contributing more robust data for cost-analysis studies assessing the financial implications of novel TED treatments. Subjects and.
This study evaluated the clinical histories of 660 patients diagnosed with GD from 1999 to 2019. The patients were categorized into four groups based on the presence and severity of TED.
The prevalence of TED within the study population, categorized according to severity, was as follows: absent (n = 325; 49%), mild (n = 221; 33%), moderate to severe (n = 107; 16%), and sight-threatening (n = 7; 1%). A significant correlation was observed between older age at diagnosis, smoking, larger goiters, and the presence and severity of TED.
The prevalence of TED identified in this single-center study contributes valuable insights for the design of cost-analysis studies and the assessment of the financial implications of novel treatments for TED within both the public and private healthcare systems in Brazil.
格雷夫斯病（GD）是全球甲状腺功能亢进的主要原因，40%的患者会发展为甲状腺眼病（TED）。近年来，TED的治疗选择有了进展。本研究旨在调查巴西一个单一中心的TED患病率，为评估新型TED治疗的财务影响的成本分析研究提供更有力的数据。对象与方法：本研究评估了1999年至2019年期间660例诊断为GD的患者的临床病史。根据TED的存在情况和严重程度将患者分为四组。结果：根据严重程度分类，研究人群中TED的患病率如下：无（n = 325；49%）、轻度（n = 221；33%）、中度至重度（n = 107；16%）和威胁视力（n = 7；1%）。在诊断时年龄较大、吸烟、甲状腺肿较大与TED的存在和严重程度之间观察到显著相关性。结论：在这项单中心研究中确定的TED患病率为巴西公共和私营医疗系统中成本分析研究的设计以及新型TED治疗的财务影响评估提供了有价值的见解。
